大鼠中2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶对DNA的修饰作用
DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.
作者信息
Takayama K, Yamashita K, Wakabayashi K, Sugimura T, Nagao M
机构信息
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1989 Dec;80(12):1145-8. doi: 10.1111/j.1349-7006.1989.tb01644.x.
Abstract
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine by weight in cooked foods. This mutagen was found to produce DNA adducts in all ten tested organs of rats using the 32P-postlabeling method. The level of DNA adducts in the pancreas, kidney and liver increased dose-dependently and feeding time-dependently up to four weeks. When diet containing 0.05% PhIP was given to rats for four weeks, levels of PhIP-DNA adducts were relatively high in the lung, pancreas and heart, being around 20 per 10(7) nucleotides, and lowest in the liver, being 2.20 per 10(7) nucleotides. Thus, PhIP showed a unique feature in the formation of DNA adducts compared to other mutagenic and carcinogenic heterocyclic amines, which produce the highest level of DNA adducts in the liver.
摘要
2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）是烹饪食品中按重量计最丰富的诱变杂环胺。使用³²P后标记法发现，这种诱变剂在大鼠所有十个受试器官中均能产生DNA加合物。胰腺、肾脏和肝脏中的DNA加合物水平在长达四周的时间内呈剂量依赖性和喂食时间依赖性增加。当给大鼠喂食含0.05%PhIP的饮食四周时，肺、胰腺和心脏中的PhIP-DNA加合物水平相对较高，约为每10⁷个核苷酸20个，而肝脏中最低，为每10⁷个核苷酸2.20个。因此，与其他诱变和致癌杂环胺相比，PhIP在DNA加合物形成方面表现出独特的特征，其他杂环胺在肝脏中产生的DNA加合物水平最高。
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