Wu Kun-Peng, Li Qiang, Lin Fu-Xiang, Li Jun, Wu Lu-Min, Li Wei, Yang Qiao-Zhu
Cancer Center, Heyuan People's hospital, Heyuan, Guangdong, 517000, China,
Tumour Biol. 2014 Dec;35(12):12489-95. doi: 10.1007/s13277-014-2567-8. Epub 2014 Sep 7.
MT1-MMP exhibits diverse expressions in patients with cancer and could be considered as potential prognostic biomarker of cancer. We performed a meta-analysis aiming to provide more sufficient evidence that MT1-MMP expression is associated with poor overall survival in several types of cancers. We systematically searched the studies from databases and carefully identified based on eligibility criteria. The association between MT1-MMP expression and overall survival in cancers was estimated using Review Manager. A total of 11 literatures which included 1,918 cancer patients were combined in the final analysis. Meta-analysis revealed that MT1-MMP overexpression was associated with an unfavorable overall survival and the pooled hazard ratio (HR) and corresponding 95 % confidence interval (CI) was 2.46 (95 % CI 1.75-3.47). From subgroup analyses, we identified that MT1-MMP was an independent prognostic factor for lung cancer and gastric cancer, and HRs (95 % CI) were 3.73 (95 % CI 2.67-5.21) and 2.46 (95 % CI 1.69-3.59), respectively. In conclusion, MT1-MMP is a potential prognostic factor in human cancers.
基质金属蛋白酶-1（MT1-MMP）在癌症患者中表现出多种表达，可被视为癌症潜在的预后生物标志物。我们进行了一项荟萃分析，旨在提供更充分的证据，证明MT1-MMP表达与几种癌症患者较差的总生存期相关。我们系统地检索了数据库中的研究，并根据纳入标准仔细筛选。使用RevMan软件评估MT1-MMP表达与癌症患者总生存期之间的关联。最终分析纳入了11篇文献，共1918例癌症患者。荟萃分析显示，MT1-MMP过表达与不良总生存期相关，合并风险比（HR）及相应的95%置信区间（CI）为2.46（95%CI 1.75-3.47）。亚组分析表明，MT1-MMP是肺癌和胃癌的独立预后因素，HR（95%CI）分别为3.73（95%CI 2.67-?5.21）和2.46（95%CI 1.69-3.59）。总之，MT1-MMP是人类癌症潜在的预后因素。 （注：原文中“5.21”前的“?”为疑似错误字符，翻译时保留原文形式）
