Rendina Domenico, De Filippo Gianpaolo, Muscariello Riccardo, De Palma Daniela, Fiengo Anna, De Pascale Francesca, Strazzullo Pasquale
Department of Clinical Medicine and Surgery, Excellence Center of Hypertension, "Federico II University" Medical School, via Sergio Pansini 5, 80131, Naples, Italy.
High Blood Press Cardiovasc Prev. 2014 Dec;21(4):251-6. doi: 10.1007/s40292-014-0060-5. Epub 2014 Sep 9.
Recent clinical and experimental studies suggest that vitamin D status could play a significant role in the pathogenesis of cardiometabolic disorders as well as in their clinical severity. In particular, low vitamin D levels appear to increase the risk of major cardiovascular events in apparently healthy individuals and to worsen the prognosis quoad vitam and quoad valetudinem following a cardiovascular event. The relevance of these observations is amplified by the high prevalence of vitamin D deficiency and insufficiency that affect over one billion individuals at all ages worldwide. Randomized controlled trials are currently underway in U.S., Europe and Oceania to demonstrate a cause-effect relationship by assessing the effects of vitamin D supplementation on various cardiovascular outcomes. Aim of this review is to point out the more recent advances in knowledge about the relationship between vitamin D status and the incidence, prevalence and pathogenesis of more common cardiometabolic disorders.
近期的临床和实验研究表明，维生素D状态可能在心脏代谢紊乱的发病机制及其临床严重程度中发挥重要作用。特别是，维生素D水平低似乎会增加看似健康个体发生主要心血管事件的风险，并在心血管事件后在生命质量和健康状况方面恶化预后。全球所有年龄段超过10亿人受到维生素D缺乏和不足的影响，这些观察结果的相关性因这一高患病率而被放大。目前美国、欧洲和大洋洲正在进行随机对照试验，通过评估补充维生素D对各种心血管结局的影响来证明因果关系。本综述的目的是指出关于维生素D状态与更常见心脏代谢紊乱的发病率、患病率和发病机制之间关系的最新知识进展。
