Mochizuki Noriko, Yamamoto Teiko, Enaida Hiroshi, Ishibashi Tatsuro, Yamashita Hidetoshi
Department of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagata, Yamagata, 990-9585, Japan,
Jpn J Ophthalmol. 2014 Nov;58(6):455-61. doi: 10.1007/s10384-014-0345-1. Epub 2014 Sep 9.
Indocyanine green (ICG), an adjuvant used for peeling of the internal limiting membrane (ILM) during vitreous surgery for idiopathic macular hole (MH), has been reported to be toxic, possibly affecting postoperative visual acuity. We compared the long-term outcomes (within 2 years) of brilliant blue G (BBG), ICG, and triamcinolone acetonide (TA).
This study involved 97 eyes of 94 patients who underwent vitreous surgery for MH at the Yamagata University Hospital between June 2002 and November 2010. The surgical adjuvants used were BBG for 15 eyes, ICG for 61 eyes, and TA for 21 eyes. We compared the postoperative visual acuities, initial closure rates, final closure rates, and complications of the 3 groups.
In all 3 groups, the visual acuity significantly improved after surgery. The magnitude of the improvement at 2 years after surgery was significantly better in the BBG group than in the ICG group (Mann-Whitney test, P = 0.020). The postoperative visual acuity did not significantly differ between the BBG and TA groups (P = 0.627) or between the ICG and TA groups (P =0 .137). Thus, the surgery using BBG resulted in a significantly better outcome in visual acuity than did the surgery using ICG. The 3 groups did not differ in initial or final closure rates or in incidence of complications.
Analysis of the long-term outcomes of vitreous surgeries provided evidence that BBG is a useful adjuvant for ILM peeling.
吲哚菁绿（ICG）是用于特发性黄斑裂孔（MH）玻璃体手术中内界膜（ILM）剥除的一种辅助剂，据报道其具有毒性，可能影响术后视力。我们比较了亮蓝G（BBG）、ICG和曲安奈德（TA）的长期（2年内）疗效。
本研究纳入了2002年6月至2010年11月间在山形大学医院接受MH玻璃体手术的94例患者的97只眼。使用的手术辅助剂为：15只眼使用BBG，61只眼使用ICG，21只眼使用TA。我们比较了三组的术后视力、初始闭合率、最终闭合率及并发症。
所有三组术后视力均显著提高。术后2年时，BBG组视力改善程度显著优于ICG组（曼-惠特尼检验，P = 0.020）。BBG组与TA组之间（P = 0.627）以及ICG组与TA组之间（P = 0.137）术后视力无显著差异。因此，使用BBG的手术在视力方面的效果显著优于使用ICG的手术。三组在初始或最终闭合率以及并发症发生率方面无差异。
玻璃体手术长期疗效分析表明，BBG是ILM剥除的一种有用辅助剂。
