Razavi Sayed Mohammad, Ghalayani Parichehr, Salehi Mohammad Reza, Attarzadeh Hajar, Shahmoradi Mahdi
Associate Professor, Oral Pathology Department and Torabinejad Dental Research center, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2009 Fall;6(2):82-6.
Oral lichen planus (OLP) is a common chronic inflammatory mucocutaneous disease. Clinical diagnosis of OLP requires clinical work-up and histologic examination to rule out possible dysplasia and carcinoma. It is possible that oral mucosal viral infections including HPV infection may have a causative role in OLP pathogenesis. The aim of this study was to examine the coincidence of human papilloma virus type 18 and oral lichen planus.
This study was a case-control study. Twenty nine paraffinized specimens of previously diagnosed oral lichen planus and 14 paraffinized specimens of nonpathogenic mucosa were studied. Polymerase Chain Reaction (PCR) analyze used for detection of DNA HPV 18. The data were analyzed with SPSS software and Fisher's exact test was used to find the possible relation between HPV18 infection and oral lichen planus.
Nine out of 29 (31.0%) lichen planus samples and one out of 14 (7.1%) controls were HPV 18 positive. No significant correlation (P = 0.128) was observed between HPV18 infection and oral lichen planus.
According to the findings there might be a co-incidence of human papilloma virus type 18 and oral lichen planus.
口腔扁平苔藓（OLP）是一种常见的慢性炎症性黏膜皮肤疾病。OLP的临床诊断需要进行临床检查和组织学检查，以排除可能的发育异常和癌变。包括人乳头瘤病毒（HPV）感染在内的口腔黏膜病毒感染可能在OLP的发病机制中起致病作用。本研究的目的是检测18型人乳头瘤病毒与口腔扁平苔藓的相关性。
本研究为病例对照研究。研究了29份先前诊断为口腔扁平苔藓的石蜡标本和14份非致病性黏膜的石蜡标本。采用聚合酶链反应（PCR）分析检测HPV 18 DNA。数据采用SPSS软件进行分析，采用Fisher精确检验来发现HPV18感染与口腔扁平苔藓之间的可能关系。
29份扁平苔藓样本中有9份（31.0%）HPV 18呈阳性，14份对照中有1份（7.1%）呈阳性。未观察到HPV18感染与口腔扁平苔藓之间存在显著相关性（P = 0.128）。
根据研究结果，18型人乳头瘤病毒与口腔扁平苔藓之间可能存在相关性。
