Alfarsi Mohammed A, Hamlet Stephen M, Ivanovski Saso
Griffith Health Institute, School of Dentistry and Oral Health, Griffith University.
Dent Mater J. 2014;33(6):749-56. doi: 10.4012/dmj.2013-221. Epub 2014 Oct 11.
Titanium implant surface modification is a key strategy used to enhance osseointegration. Platelets are the first cells that interact with the implant surface whereupon they release a wide array of proteins that influence the subsequent healing process. This study therefore investigated the effect of titanium surface modification on the attachment and activation of human platelets. The surface characteristics of three titanium surfaces: smooth (SMO), micro-rough (SLA) and hydrophilic micro-rough (SLActive) and the subsequent attachment and activation of platelets following exposure to these surfaces were determined. The SLActive surface showed the presence of significant nanoscale topographical features. While attached platelets appeared to be morphologically similar, significantly fewer platelets attached to the SLActive surface compared to both the SMO and SLA surfaces. The SLActive surface however induced the release of the higher levels of chemokines β-thromboglobulin and platelet factor 4 from platelets. This study shows that titanium surface topography and chemistry have a significant effect on platelet activation and chemokine release.
钛植入物表面改性是用于增强骨整合的关键策略。血小板是首先与植入物表面相互作用的细胞，随后它们会释放出一系列影响后续愈合过程的蛋白质。因此，本研究调查了钛表面改性对人血小板附着和激活的影响。测定了三种钛表面的表面特性：光滑（SMO）、微粗糙（SLA）和亲水微粗糙（SLActive），以及暴露于这些表面后血小板随后的附着和激活情况。SLActive表面呈现出显著的纳米级形貌特征。虽然附着的血小板在形态上似乎相似，但与SMO和SLA表面相比，附着在SLActive表面的血小板明显更少。然而，SLActive表面诱导血小板释放更高水平的趋化因子β-血小板球蛋白和血小板因子4。本研究表明，钛表面形貌和化学性质对血小板激活和趋化因子释放有显著影响。
