Lei L, Li T, Ding X, Ma W, Zhu X, Atik A, Hu Y, Tang S
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.
Eye (Lond). 2015 Jan;29(1):106-14. doi: 10.1038/eye.2014.245. Epub 2014 Oct 17.
To evaluate the long-term clinical efficacy and safety of gas tamponade combined with laser photocoagulation for optic disc pit maculopathy.
Seven consecutive patients with unilateral maculopathy associated with optic disc pit and one patient with bilateral optic disc pit maculopathy were given octafluoropropane (C3F8) tamponade combined with focal laser photocoagulation treatment. Patients were followed up for 21-62 months after treatment. Main outcomes were determined by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA).
Treatment with C3F8 tamponade followed by laser photocoagulation in ODP maculopathy patients resulted in resolution of sub-retinal and/or intra-retinal fluid in six out of eight patients. The remaining two patients had significant reduction in fluid, as determined by OCT, and funduscopy, as well as an improvement in anatomical architecture. Visual acuity improved obviously in seven eyes and remained stable in two eyes. Central visual field loss after photocoagulation was not clinically appreciable by visual field examination. No post-operative complications of maculopathy occurred during the follow-up period.
Although repeated treatment was needed in some patients, C3F8 tamponade combined with laser photocoagulation is still a simple, effective, minimally invasive, and economic therapy for optic disc pit maculopathy.
评估气体填塞联合激光光凝治疗视盘小凹黄斑病变的长期临床疗效和安全性。
连续7例单侧黄斑病变合并视盘小凹患者及1例双侧视盘小凹黄斑病变患者接受八氟丙烷(C3F8)填塞联合局灶性激光光凝治疗。治疗后对患者进行21至62个月的随访。主要观察指标通过光学相干断层扫描(OCT)和最佳矫正视力(BCVA)确定。
视盘小凹黄斑病变患者接受C3F8填塞后再行激光光凝治疗,8例患者中有6例视网膜下和/或视网膜内积液消退。通过OCT和眼底镜检查确定,其余2例患者的积液显著减少,且解剖结构有所改善。7只眼视力明显提高,2只眼视力保持稳定。光凝后中央视野缺损经视野检查在临床上未发现明显异常。随访期间未发生黄斑病变的术后并发症。
尽管部分患者需要重复治疗,但C3F8填塞联合激光光凝仍是治疗视盘小凹黄斑病变的一种简单、有效、微创且经济的方法。