Karayiannis P, Petrovic L M, Fry M, Moore D, Enticott M, McGarvey M J, Scheuer P J, Thomas H C
Academic Department of Medicine, St. Mary's Hospital Medical School, London, England.
Hepatology. 1989 Feb;9(2):186-92. doi: 10.1002/hep.1840090204.
Three tamarins (Saguinus labiatus), two of which had previously been infected with hepatitis A virus and parenteral non-A, non-B hepatitis, were inoculated intravenously with the agent of GB hepatitis. All three animals developed alanine aminotransferase abnormalities 2 weeks after inoculation. Peak alanine aminotransferase levels were recorded 4 weeks postinoculation. These declined thereafter but continued to fluctuate at abnormal levels for 32 weeks. Liver biopsies showed liver cell swelling and inflammation with focal necrosis. Portal tracts and areas around central veins were heavily infiltrated with mononuclear cells. A fourth animal (no previous exposure to hepatitis viruses) inoculated with GB was killed on Day 15 postinoculation. Serum and extracts of liver and feces from this day were used as inocula for three other animals. Only the serum and liver extract transmitted GB hepatitis. The fecal specimen did not transmit and a fecal extract taken at a later date from another animal was also noninfectious. GB hepatitis virus is distinct from the viruses causing Type A and blood-borne non-A, non-B-hepatitis. Although the virus is present in serum and has previously been transmitted per os, it is not shed in feces.
三只绢毛猴（白唇狨），其中两只先前感染过甲型肝炎病毒和肠道外非甲非乙型肝炎，静脉接种GB型肝炎病原体。接种后2周，所有三只动物均出现丙氨酸转氨酶异常。接种后4周记录到丙氨酸转氨酶峰值水平。此后这些水平下降，但在32周内持续在异常水平波动。肝活检显示肝细胞肿胀、炎症伴局灶性坏死。门管区和中央静脉周围区域有大量单核细胞浸润。第四只动物（先前未接触过肝炎病毒）接种GB后于接种后第15天处死。当天该动物的血清、肝和粪便提取物用作另外三只动物的接种物。只有血清和肝提取物传播GB型肝炎。粪便标本未传播，后来从另一只动物采集的粪便提取物也无传染性。GB型肝炎病毒不同于引起甲型肝炎和血源性非甲非乙型肝炎的病毒。虽然该病毒存在于血清中且先前已通过口服传播，但它不在粪便中排出。
