Low D E, McGeer A, Poon R
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Antimicrob Agents Chemother. 1989 Apr;33(4):585-8. doi: 10.1128/AAC.33.4.585.
The in vitro activities of daptomycin, teicoplanin, and three other antimicrobial agents were determined against 105 strains of Staphylococcus haemolyticus and 92 strains of Staphylococcus epidermidis. The MICs for 90% of strains tested (MIC90s) of fusidic acid and rifampin were less than or equal to 0.25 microgram/ml. The MIC90s of daptomycin and vancomycin were less than or equal to 4 micrograms/ml. Teicoplanin had a comparable MIC90 of less than or equal to 4 micrograms/ml for isolates of S. epidermidis. However, MIC90s were 8 and 16 micrograms/ml for oxacillin-susceptible and oxacillin-resistant S. haemolyticus, respectively. Disk diffusion tests were evaluated for daptomycin and teicoplanin. Disks with 30 micrograms of teicoplanin performed satisfactorily when S. epidermidis was tested, but when S. haemolyticus was tested, there was a very major error rate of 10% and a minor error rate of 38%.
测定了达托霉素、替考拉宁和其他三种抗菌药物对105株溶血葡萄球菌和92株表皮葡萄球菌的体外活性。夫西地酸和利福平对90%受试菌株的最低抑菌浓度（MIC90）小于或等于0.25微克/毫升。达托霉素和万古霉素的MIC90小于或等于4微克/毫升。替考拉宁对表皮葡萄球菌分离株的MIC90与之相当，小于或等于4微克/毫升。然而，对苯唑西林敏感和耐药的溶血葡萄球菌的MIC90分别为8和16微克/毫升。对达托霉素和替考拉宁进行了纸片扩散试验评估。当检测表皮葡萄球菌时，含30微克替考拉宁的纸片表现良好，但检测溶血葡萄球菌时，有10%的极重大错误率和38%的微小错误率。
