评估血清胃饥饿素、C反应蛋白和白细胞介素-6水平与炎症性肠病疾病活动度之间的关系。

Evaluation of the relationship between serum ghrelin, C-reactive protein and interleukin-6 levels, and disease activity in inflammatory bowel diseases.

作者信息

Cekic Cem, Arabul Mahmut, Alper Emrah, Pakoz Zehra Betul Kocal, Saritas Elif, Ünsal Belkis

出版信息

Hepatogastroenterology. 2014 Jul-Aug;61(133):1196-200.

Abstract

BACKGROUND/AIMS: Ghrelin is a 28 aminoasid peptide hormone, have generally focused upon this peptide’s role upon growth and energy metabolism. Recently, studies investigating ghrelin’s effect upon inflammation and immune response have gained importance. We aimed to compare the effectiveness of ghrelin levels, Creactive protein and interleukin-6 levels in establishing disease activity.

METHODOLOGY

52 cases with ulcerative colitis and 33 with Crohn’s disease, total 85 patients, were included in this study. The serum ghrelin levels of the patients in remission and of those with active disease were compared.

RESULTS

The mean serum ghrelin level in active patients (1243 ± 648 pg/ml), was found to be higher than those in remission (466 ± 214 pg/ml) (p<0.001). In establishing the disease activity, CRP is a the most effective marker compared to the other two inflammatory markers. AUC values were established as; CRP: 0.947 (95% CI,0.903-0.992),ghrelin:0.934(95% CI, 0.884-0.984) and interleukin-6: 0.756 (95% CI, 0.648- 0.864).

DISCUSSION

Serum ghrelin level can be used with CRP as an important marker in establishing the mucosal damage in inflammatory bowel diseases.

摘要

背景/目的：胃饥饿素是一种由28个氨基酸组成的肽类激素，人们普遍关注该肽在生长和能量代谢中的作用。最近，研究胃饥饿素对炎症和免疫反应影响的研究变得越来越重要。我们旨在比较胃饥饿素水平、C反应蛋白和白细胞介素-6水平在确定疾病活动度方面的有效性。

方法

本研究纳入了52例溃疡性结肠炎患者和33例克罗恩病患者，共85例患者。比较了缓解期患者和疾病活动期患者的血清胃饥饿素水平。

结果

发现活动期患者的平均血清胃饥饿素水平（1243±648 pg/ml）高于缓解期患者（466±214 pg/ml）（p<0.001）。在确定疾病活动度方面，与其他两种炎症标志物相比，CRP是最有效的标志物。AUC值确定为：CRP：0.947（95%CI，0.903-0.992），胃饥饿素：0.934（95%CI，0.884-0.984），白细胞介素-6：0.756（95%CI，0.648-0.864）。