Kang Hyeon Hui, Kang Ji Young, Ha Jick Hwan, Lee Jongmin, Kim Sung Kyoung, Moon Hwa Sik, Lee Sang Haak
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
PLoS One. 2014 Dec 4;9(12):e114463. doi: 10.1371/journal.pone.0114463. eCollection 2014.
Obesity is a major risk factor for the development of obstructive sleep apnea (OSA). Although clinical and epidemiological studies have shown that OSA and obesity are strongly associated, few Asian studies have examined the associations between anthropometric obesity indices and OSA, especially in the Korean population. The purpose of this study was to evaluate the influence of anthropometric obesity indices on OSA in a Korean population.
Anthropometric indices, including neck circumference, waist circumference, and body mass index, were assessed in 383 consecutive subjects with suspected OSA.
Of the 383 subjects assessed, 316 (82.5%) were diagnosed with OSA. Neck circumference (r = 0.518), waist circumference (r = 0.570), and body mass index (r = 0.512) were correlated with the apnea-hypopnea index (p<0.001, for all). After adjusting for age, sex, alcohol consumption, and smoking, a logistic regression model showed that neck circumference [odds ratio (OR), 1.414; p<0.001)], waist circumference (OR, 1.114; p<0.001), and body mass index (OR, 1.364; p<0.001) were associated with OSA. The linear regression model showed that neck circumference (β = 3.748, p<0.001), waist circumference (β = 1.272, p<0.001), and body mass index (β = 3.082, p<0.001) were associated with apnea-hypopnea index. The cut-off values for predicting OSA were determined as 34.5 cm for neck circumference, 76.5 cm for waist circumference, and 23.05 kg/m2 for body mass index for females, and 38.75 cm for neck circumference, 88.5 cm for waist circumference, and 24.95 kg/m2 for body mass index for males.
Increased anthropometric indices were significantly associated with the presence and severity of OSA in a Korean population. In addition, this study demonstrated the cut-off values for body mass index, waist circumference, and neck circumference for increased OSA risk.
肥胖是阻塞性睡眠呼吸暂停（OSA）发生的主要危险因素。尽管临床和流行病学研究表明OSA与肥胖密切相关，但很少有亚洲研究探讨人体测量肥胖指数与OSA之间的关联，尤其是在韩国人群中。本研究的目的是评估人体测量肥胖指数对韩国人群中OSA的影响。
对383例连续的疑似OSA患者进行人体测量指数评估，包括颈围、腰围和体重指数。
在评估的383例受试者中，316例（82.5%）被诊断为OSA。颈围（r = 0.518）、腰围（r = 0.570）和体重指数（r = 0.512）与呼吸暂停低通气指数相关（所有p<0.001）。在调整年龄、性别、饮酒和吸烟因素后，逻辑回归模型显示颈围[比值比（OR），1.414；p<0.001]、腰围（OR，1.114；p<0.001）和体重指数（OR，1.364；p<0.001）与OSA相关。线性回归模型显示颈围（β = 3.748，p<0.001）、腰围（β = 1.272，p<0.001）和体重指数（β = 3.082，p<0.001）与呼吸暂停低通气指数相关。预测OSA的截断值确定为女性颈围34.5 cm、腰围76.5 cm、体重指数23.05 kg/m²，男性颈围38.75 cm、腰围88.5 cm、体重指数24.95 kg/m²。
在韩国人群中，人体测量指数的增加与OSA的存在和严重程度显著相关。此外，本研究还证明了体重指数、腰围和颈围增加OSA风险的截断值。
