Evol Appl. 2010 Jul;3(4):375-90. doi: 10.1111/j.1752-4571.2010.00124.x. Epub 2010 Mar 29.
Resistance to pesticides and drugs led to the development of theoretical models aimed at identifying the main factors of resistance evolution and predicting the efficiency of resistance management strategies. We investigated the various ways in which the evolution of resistance has been modelled over the last three decades, by reviewing 187 articles published on models of the evolution of resistance to all major classes of pesticides and drugs. We found that (i) the technical properties of the model were most strongly influenced by the class of pesticide or drug and the target organism, (ii) the resistance management strategies studied were quite similar for the different classes of pesticides or drugs, except that the refuge strategy was mostly used in models of the evolution of resistance to insecticidal proteins, (iii) economic criteria were rarely used to evaluate the evolution of resistance and (iv) the influence of mutation, migration and drift on the speed of resistance development has been poorly investigated. We propose guidelines for the future development of theoretical models of the evolution of resistance. For instance, we stress the potential need to give more emphasis to the three evolutionary forces migration, mutation and genetic drift rather than simply selection.
对杀虫剂和药物的抗性促使了理论模型的发展，这些模型旨在确定抗性进化的主要因素并预测抗性管理策略的效果。我们通过回顾187篇关于所有主要类别的杀虫剂和药物抗性进化模型的文章，研究了过去三十年中对抗性进化进行建模的各种方式。我们发现：（i）模型的技术特性受杀虫剂或药物类别以及目标生物的影响最大；（ii）除了避难所策略主要用于杀虫蛋白抗性进化模型外，针对不同类别的杀虫剂或药物所研究的抗性管理策略非常相似；（iii）很少使用经济标准来评估抗性进化；（iv）对突变、迁移和漂变对抗性发展速度的影响研究不足。我们为抗性进化理论模型的未来发展提出了指导方针。例如，我们强调可能需要更加强调迁移、突变和遗传漂变这三种进化力量，而不仅仅是选择。
