Huy Bùi Vũ, Vernavong Kanxay, Kính Nguyễn Văn
Hanoi Medical University, Hanoi 10000, Vietnam.
National Hospital of Tropical Diseases, 78 Giai Phong Road, Dong Da District, Hanoi 10000, Vietnam.
AIDS Res Treat. 2014;2014:581021. doi: 10.1155/2014/581021. Epub 2014 Dec 8.
Aim. To examine prevalence and characterization of HBV and HCV coinfection among HIV/AIDS patients. Methods. This cross-sectional, retrospective study analyzed 724 HIV/AIDS patients in the HIV clinic at the National Hospital of Tropical Diseases (NHTD), from 5/2005 to 4/2011. Results. The prevalence of HBV, HCV, and HIV coinfection was 50.3% (364/724), of which HbsAg, HCV, and both of HbsAg, and HCV positivity were 8.4%, 35.4%, and 6.5%, respectively. The cohort (364 patients) with HBV, HCV, and HIV coinfection live in the 30 provinces/cities in the North and Central area of Vietnam. We found statistically significant associations between heightened risk of coinfection with HIV and HCV in the age group 30-39 years (P < 0.001), male gender (P < 0.001), never married patients (P < 0.001), patients with a history of injection drug use (P < 0.001), and clinical stages 2-4 (P < 0.001). Coinfection with HBV/HIV was statistically significant associations between heightened risk of marital status (never married) (P < 0.001) and those who reported transmission through sexual intercourse. Conclusion. Coinfection with viral hepatitis is common in HIV patients; further study of the impact and evolution of coinfection is necessary to find effective treatment algorithms.
目的。研究HIV/AIDS患者中HBV和HCV合并感染的患病率及特征。方法。这项横断面回顾性研究分析了2005年5月至2011年4月期间在国家热带病医院（NHTD）HIV门诊的724例HIV/AIDS患者。结果。HBV、HCV和HIV合并感染的患病率为50.3%（364/724），其中HBsAg、HCV以及HBsAg和HCV均阳性的比例分别为8.4%、35.4%和6.5%。HBV、HCV和HIV合并感染的队列（364例患者）分布在越南北部和中部的30个省/市。我们发现，在30 - 39岁年龄组（P < 0.001）、男性（P < 0.001）、未婚患者（P < 0.001）、有注射吸毒史的患者（P < 0.001）以及临床分期为2 - 4期的患者（P < 0.001）中，HIV与HCV合并感染的风险增加存在统计学显著关联。HBV/HIV合并感染与婚姻状况（未婚）（P < 0.001）以及报告通过性交传播的患者中风险增加存在统计学显著关联。结论。病毒性肝炎合并感染在HIV患者中很常见；有必要进一步研究合并感染的影响和演变，以找到有效的治疗方案。
