de Schryver A, Rosén A, Gunvén P, Klein G
Int J Cancer. 1976 Jan 15;17(1):8-13. doi: 10.1002/ijc.2910170103.
EBV-neutralizing antibody titers were determined in 11 sera derived from African Burkitt lymphoma or nasopharyngeal carcinoma patients and in the corresponding serum fractions retained above XM 100 Diaflo membranes after low pH treatment, and after recombination of the retained and passed fractions by neutralization of the acidified samples. They were compared with the corresponding antimembrane antigen (MA) titers in seven of the same sera. While all sera tested showed substantial increase of the anti-MA activity in the retained fraction, resulting in a significantly increased mean titer, EBV neutralizing activity did not change at all after identical treatment or changed only in a random fashion, resulting in stable mean titers. It is suggested that anti-MA and neutralizing antibodies are directed against at least partly different antigens on the virus.
在来自非洲伯基特淋巴瘤或鼻咽癌患者的11份血清中，以及在低pH处理后保留于XM 100 Diaflo膜上方的相应血清组分中，还有在通过中和酸化样品使保留组分和透过组分重新组合后，测定了EBV中和抗体滴度。将它们与同7份血清中相应的抗膜抗原（MA）滴度进行比较。虽然所有检测的血清在保留组分中抗MA活性均显著增加，导致平均滴度显著升高，但相同处理后EBV中和活性根本没有变化，或只是随机变化，导致平均滴度稳定。这表明抗MA抗体和中和抗体至少部分针对病毒上不同的抗原。
