患有青紫型先天性心脏病患者的黄斑及视乳头周围视网膜神经纤维层厚度
Macular and peripapillary retinal nerve fibre layer thickness in patients with cyanotic congenital heart disease.
作者信息
de Aguiar Remigio M C, Brandt C T, Santos C C L, Arantes T E, de Aguiar M I R
机构信息
Department of Ophthalmology, Fundação Altino Ventura, Recife, Brazil.
Department of Surgery, Universidade Federal de Pernambuco, Recife, Brazil.
出版信息
Eye (Lond). 2015 Apr;29(4):465-8. doi: 10.1038/eye.2014.330. Epub 2015 Jan 16.
PURPOSE
To evaluate macular and retinal nerve fibre layer (RNFL) measurements in patients with cyanotic congenital heart disease (cCHD) using spectral domain optical coherence tomography (OCT).
PATIENTS AND METHODS
Thirty patients with cCHD (18 females and 12 males, mean age 10.9 years) and 60 healthy controls (35 females and 25 males, mean age 11.2 years) underwent complete ophthalmologic examination and OCT measurements of macular and peripapillary RNFL thickness.
RESULTS
Patients with cCHD had significantly thinner measurements in all macular subfields compared with healthy controls (P<0.001). There was no significant difference in peripapillary RNFL thickness between the two groups, with the exception of the upper quadrant, for which thickness measurements were higher in patients with cCHD (P=0.021).
CONCLUSIONS
Patients with cCHD showed a significant decrease in macular thickness and a thickened superior quadrant RNFL thickness when compared with healthy controls. This may represent the damage caused by the effect of hypoxia.
目的
使用光谱域光学相干断层扫描（OCT）评估患有青紫型先天性心脏病（cCHD）患者的黄斑和视网膜神经纤维层（RNFL）测量值。
患者与方法
30例cCHD患者（18例女性和12例男性，平均年龄10.9岁）和60例健康对照者（35例女性和25例男性，平均年龄11.2岁）接受了全面的眼科检查以及黄斑和视乳头周围RNFL厚度的OCT测量。
结果
与健康对照者相比，cCHD患者所有黄斑亚区的测量值均显著更薄（P<0.001）。两组之间视乳头周围RNFL厚度无显著差异，但上象限除外，cCHD患者该象限的厚度测量值更高（P=0.021）。
结论
与健康对照者相比，cCHD患者黄斑厚度显著降低，上象限RNFL厚度增厚。这可能代表了缺氧影响所造成的损害。
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