Do T D, Park C, Choi K, Jeong J, Vo M K, Nguyen T T, Chae C
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.
Vet Res Commun. 2015 Mar;39(1):79-85. doi: 10.1007/s11259-015-9628-3. Epub 2015 Jan 30.
The objective of this study was to compare the pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection between wild and domestic pigs based on clinical, immunological, and pathological evaluation. Upon challenge with HP-PRRSV, five wild pigs died compared to none of the domestic. Anti-PRRSV antibody titers were significantly (P < 0.05) higher in wild HP-PRRSV-infected pigs versus the domestic HP-PRRSV-infected pigs at 21 days post inoculation (dpi). Lung lesion scores at 7 dpi were also significantly (P < 0.01) higher in domestic infected pigs than wild infected pigs. The most striking difference was the viral tissue distribution between the wild and domestic HP-PRRSV-infected pigs. HP-PRRSV-positive cells were observed in bronchiolar, gastric, and renal tubular epithelial cells from wild HP-PRRSV-infected pigs only. The results in this study demonstrated a genetic difference exists between wild and domestic pigs, which could results in different clinical signs, immunological responses, and pathological outcomes to HP-PRRSV infection.
本研究的目的是基于临床、免疫学和病理学评估，比较高致病性猪繁殖与呼吸综合征病毒（HP-PRRSV）在野猪和家猪之间感染的致病性。用HP-PRRSV攻击后，五只野猪死亡，而家猪无一死亡。在接种后21天（dpi），野生HP-PRRSV感染猪的抗PRRSV抗体滴度显著（P < 0.05）高于家猪HP-PRRSV感染猪。在7 dpi时，家猪感染猪的肺损伤评分也显著（P < 0.01）高于野猪感染猪。最显著的差异是野生和家猪HP-PRRSV感染猪之间的病毒组织分布。仅在野生HP-PRRSV感染猪的细支气管、胃和肾小管上皮细胞中观察到HP-PRRSV阳性细胞。本研究结果表明，野猪和家猪之间存在遗传差异，这可能导致对HP-PRRSV感染的临床症状、免疫反应和病理结果不同。
