Wass Sam V, Jones Emily J H, Gliga Teodora, Smith Tim J, Charman Tony, Johnson Mark H
Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Centre for Brain and Cognitive Development, Birkbeck, University of London, UK.
Sci Rep. 2015 Feb 6;5:8284. doi: 10.1038/srep08284.
Little is known about how spontaneous attentional deployment differs on a millisecond-level scale in the early development of autism spectrum disorders (ASD). We measured fine-grained eye movement patterns in 6-to 9-month-old infants at high or low familial risk (HR/LR) of ASD while they viewed static images. We observed shorter fixation durations (i.e. the time interval between saccades) in HR than LR infants. Preliminary analyses indicate that these results were replicated in a second cohort of infants. Fixation durations were shortest in those infants who went on to receive an ASD diagnosis at 36 months. While these findings demonstrate early-developing atypicality in fine-grained measures of attentional deployment early in the etiology of ASD, the specificity of these effects to ASD remains to be determined.
关于在自闭症谱系障碍（ASD）早期发展过程中，自发注意力分配在毫秒级尺度上如何不同，目前所知甚少。我们测量了6至9个月大、患ASD高或低家族风险（HR/LR）的婴儿在观看静态图像时的精细眼动模式。我们观察到，HR组婴儿的注视持续时间（即扫视之间的时间间隔）比LR组婴儿短。初步分析表明，这些结果在第二批婴儿中得到了重复。在36个月时被诊断为ASD的婴儿中，注视持续时间最短。虽然这些发现表明在ASD病因早期，注意力分配的精细测量中存在早期发展的非典型性，但这些效应对ASD的特异性仍有待确定。
