耐热直接溶血素（TDH）和TDH相关溶血素（TRH）在副溶血性弧菌中的作用。
Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus.
作者信息
Raghunath Pendru
机构信息
Department of Microbiology, Dr. VRK Women's Medical College Teaching Hospital and Research Centre Hyderabad, India.
出版信息
Front Microbiol. 2015 Jan 22;5:805. doi: 10.3389/fmicb.2014.00805. eCollection 2014.
Abstract
Vibrio parahaemolyticus is the leading cause of seafood borne bacterial gastroenteritis in the world, often associated with the consumption of raw or undercooked seafood. However, not all strains of V. parahaemolyticus are pathogenic. The thermostable direct hemolysin (TDH) or TDH-related hemolysin (TRH) encoded by tdh and trh genes, respectively, are considered major virulence factors in V. parahaemolyticus. However, about 10% of clinical strains do not contain tdh and/or trh. Environmental isolates of V. parahaemolyticus lacking tdh and/or trh are also highly cytotoxic to human gastrointestinal cells. Even in the absence of these hemolysins, V. parahaemolyticus remains pathogenic indicating other virulence factors exist. This mini review aims at discussing the possible roles of tdh and trh genes in clinical and environmental isolates of V. parahaemolyticus.
摘要
副溶血性弧菌是全球食源性细菌性肠胃炎的主要病因，通常与食用生的或未煮熟的海鲜有关。然而，并非所有副溶血性弧菌菌株都具有致病性。分别由tdh和trh基因编码的耐热直接溶血素（TDH）或TDH相关溶血素（TRH）被认为是副溶血性弧菌的主要毒力因子。然而，约10%的临床菌株不含有tdh和/或trh。缺乏tdh和/或trh的副溶血性弧菌环境分离株对人类胃肠道细胞也具有高度细胞毒性。即使在没有这些溶血素的情况下，副溶血性弧菌仍具有致病性，这表明还存在其他毒力因子。本综述旨在探讨tdh和trh基因在副溶血性弧菌临床和环境分离株中的可能作用。
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