巨细胞病毒（CMV）血清阳性会降低B细胞对流感疫苗的反应。
Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine.
作者信息
Frasca Daniela, Diaz Alain, Romero Maria, Landin Ana Marie, Blomberg Bonnie B
机构信息
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
出版信息
Vaccine. 2015 Mar 17;33(12):1433-9. doi: 10.1016/j.vaccine.2015.01.071. Epub 2015 Feb 7.
Abstract
Cytomegalovirus (CMV)-seropositivity has been shown to have a negative effect on influenza vaccine-specific antibody responses. In this paper, we confirm and extend these results showing for the first time, a negative association between CMV-seropositivity and B cell predictive biomarkers of optimal vaccine responses. These biomarkers are switched memory B cells and AID in CpG-stimulated B cell cultures measured before vaccination which positively correlate with the serum response to the influenza vaccine. We also found that CMV-seropositivity is associated with increased levels of B cell-intrinsic inflammation and these both correlate with lower B cell function. Finally, CMV-seropositivity is associated with decreased percentages of individuals responding to the vaccine in both young and elderly individuals.
摘要
巨细胞病毒（CMV）血清阳性已被证明对流感疫苗特异性抗体反应有负面影响。在本文中，我们首次证实并扩展了这些结果，表明CMV血清阳性与最佳疫苗反应的B细胞预测生物标志物之间存在负相关。这些生物标志物是在接种疫苗前测量的CpG刺激的B细胞培养物中的转换记忆B细胞和AID，它们与流感疫苗的血清反应呈正相关。我们还发现，CMV血清阳性与B细胞内在炎症水平升高有关，而这两者都与较低的B细胞功能相关。最后，CMV血清阳性与年轻人和老年人中对疫苗有反应的个体百分比降低有关。
相似文献
1
Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine.巨细胞病毒（CMV）血清阳性会降低B细胞对流感疫苗的反应。
Vaccine. 2015 Mar 17;33(12):1433-9. doi: 10.1016/j.vaccine.2015.01.071. Epub 2015 Feb 7.
2
Aging, cytomegalovirus (CMV) and influenza vaccine responses.衰老、巨细胞病毒（CMV）与流感疫苗反应。
Hum Vaccin Immunother. 2016 Mar 3;12(3):682-90. doi: 10.1080/21645515.2015.1105413.
3
Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.老年人中流感疫苗介导的保护作用：流感感染、巨细胞病毒血清状态和疫苗剂量的影响。
Exp Gerontol. 2018 Jul 1;107:116-125. doi: 10.1016/j.exger.2017.09.015. Epub 2017 Sep 27.
4
Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.巨细胞病毒相关的晚期分化 CD4 T 细胞积累与流感疫苗接种后不良的体液免疫反应相关。
Vaccine. 2013 Jan 11;31(4):685-90. doi: 10.1016/j.vaccine.2012.11.041. Epub 2012 Nov 26.
5
Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults.年龄对健康成年人新型流感疫苗株抗体应答的负面影响，但潜伏性巨细胞病毒感染无此影响。
Front Immunol. 2018 Jan 29;9:82. doi: 10.3389/fimmu.2018.00082. eCollection 2018.
6
Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities.巨细胞病毒感染与长期护理机构老年居民对流感疫苗接种的反应性。
Vaccine. 2011 Jun 24;29(29-30):4869-74. doi: 10.1016/j.vaccine.2011.03.086. Epub 2011 Apr 15.
7
Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination: a systematic review and meta-analysis.潜伏性巨细胞病毒感染对流感疫苗抗体应答的影响：系统评价和荟萃分析。
Med Microbiol Immunol. 2019 Aug;208(3-4):305-321. doi: 10.1007/s00430-019-00602-z. Epub 2019 Apr 4.
8
Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging.人类抗体库的系统发育分析揭示了免疫衰老和老化的定量特征。
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1105-1110. doi: 10.1073/pnas.1617959114. Epub 2017 Jan 17.
9
Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly.老年人中细胞干扰素γ和颗粒酶B对巨细胞病毒pp65和流感N1的反应呈正相关。
Viral Immunol. 2016 Apr;29(3):169-75. doi: 10.1089/vim.2015.0071. Epub 2016 Mar 22.
10
Better Response to Influenza Virus Vaccination in Physically Trained Older Adults Is Associated With Reductions of Cytomegalovirus-Specific Immunoglobulins as Well as Improvements in the Inflammatory and CD8 T-Cell Profiles.身体训练的老年人对流感病毒疫苗接种的反应更好，与巨细胞病毒特异性免疫球蛋白的减少以及炎症和 CD8 T 细胞特征的改善有关。
Front Immunol. 2021 Oct 12;12:713763. doi: 10.3389/fimmu.2021.713763. eCollection 2021.
引用本文的文献
1
Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study.季节性流感疫苗接种后年轻人和老年人中血凝素表位变异及对连续A/维多利亚A(H1N1)毒株的抗体反应：一项初步研究
Vaccines (Basel). 2025 Jul 21;13(7):774. doi: 10.3390/vaccines13070774.
2
Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness.接种疫苗前的免疫类型和免疫熵是多种疫苗反应性的指标。
Aging Cell. 2025 Sep;24(9):e70151. doi: 10.1111/acel.70151. Epub 2025 Jul 24.
3
The Reduced Immunogenicity of Zoster Vaccines in CMV-Seropositive Older Adults Correlates with T Cell Imprinting.带状疱疹疫苗在巨细胞病毒血清阳性的老年人中免疫原性降低与T细胞印记有关。
Vaccines (Basel). 2025 Mar 22;13(4):340. doi: 10.3390/vaccines13040340.
4
Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8 T Cell Responses.年龄和潜伏性巨细胞病毒感染不影响新冠病毒-2特异性CD8 T细胞反应的强度。
Eur J Immunol. 2025 Mar;55(3):e202451565. doi: 10.1002/eji.202451565.
5
Basal T cell activation predicts yellow fever vaccine response independently of cytomegalovirus infection and sex-related immune variations.基础T细胞活化可独立于巨细胞病毒感染和性别相关免疫差异预测黄热病疫苗反应。
Cell Rep Med. 2025 Feb 18;6(2):101946. doi: 10.1016/j.xcrm.2025.101946. Epub 2025 Feb 11.
6
Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection.潜伏性巨细胞病毒感染驱动的人体对疟疾感染和疫苗接种的免疫反应异质性。
EBioMedicine. 2024 Nov;109:105419. doi: 10.1016/j.ebiom.2024.105419. Epub 2024 Oct 26.
7
miR-155 and miR-92 levels in ALL, post-transplant aGVHD, and CMV: possible new treatment options.miR-155 和 miR-92 水平在 ALL、移植后移植物抗宿主病和 CMV 中的变化：可能的新治疗选择。
J Egypt Natl Canc Inst. 2023 Jun 19;35(1):18. doi: 10.1186/s43046-023-00174-3.
8
Changes in HCMV immune cell frequency and phenotype are associated with chronic lung allograft dysfunction.巨细胞病毒免疫细胞频率和表型的变化与慢性肺移植功能障碍有关。
Front Immunol. 2023 Apr 28;14:1143875. doi: 10.3389/fimmu.2023.1143875. eCollection 2023.
9
Association of Cytomegalovirus Serostatus With Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responsiveness in Nursing Home Residents and Healthcare Workers.巨细胞病毒血清学状态与疗养院居民和医护人员中严重急性呼吸综合征冠状病毒2疫苗反应性的关联
Open Forum Infect Dis. 2023 Feb 4;10(2):ofad063. doi: 10.1093/ofid/ofad063. eCollection 2023 Feb.
10
Assessment of the Interferon-Lambda-3 Polymorphism in the Antibody Response to COVID-19 in Older Adults Seropositive for CMV.巨细胞病毒血清阳性老年人中干扰素-λ-3多态性对COVID-19抗体反应的评估。
Vaccines (Basel). 2023 Feb 18;11(2):480. doi: 10.3390/vaccines11020480.
本文引用的文献
1
Inflammation, ageing and chronic disease.炎症、衰老和慢性疾病。
Curr Opin Immunol. 2014 Aug;29:23-8. doi: 10.1016/j.coi.2014.03.007. Epub 2014 Apr 22.
2
High TNF-α levels in resting B cells negatively correlate with their response.静息B细胞中高肿瘤坏死因子-α水平与其反应呈负相关。
Exp Gerontol. 2014 Jun;54:116-22. doi: 10.1016/j.exger.2014.01.004. Epub 2014 Jan 15.
3
Young and elderly patients with type 2 diabetes have optimal B cell responses to the seasonal influenza vaccine.患有2型糖尿病的年轻和老年患者对季节性流感疫苗具有最佳的B细胞反应。
Vaccine. 2013 Aug 2;31(35):3603-10. doi: 10.1016/j.vaccine.2013.05.003. Epub 2013 May 25.
4
Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011-2012 influenza vaccine season.在 2011-2012 流感疫苗季节评估年龄对 H1N1 特异性血清 IgG1 和 IgG3 水平的影响。
Immun Ageing. 2013 Apr 22;10(1):14. doi: 10.1186/1742-4933-10-14.
5
Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.巨细胞病毒相关的晚期分化 CD4 T 细胞积累与流感疫苗接种后不良的体液免疫反应相关。
Vaccine. 2013 Jan 11;31(4):685-90. doi: 10.1016/j.vaccine.2012.11.041. Epub 2012 Nov 26.
6
AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans.AID 活动与 2009 年大流行 H1N1 疫苗接种后人体内多克隆抗体亲和力成熟呈强相关性。
PLoS Pathog. 2012 Sep;8(9):e1002920. doi: 10.1371/journal.ppat.1002920. Epub 2012 Sep 13.
7
The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection.随着年龄增长，低度全身性炎症（炎症衰老）增加，但这种现象不是由巨细胞病毒感染引起的。
Aging Cell. 2012 Oct;11(5):912-5. doi: 10.1111/j.1474-9726.2012.00849.x. Epub 2012 Jul 12.
8
The impact of CMV infection on survival in older humans.巨细胞病毒感染对老年人存活的影响。
Curr Opin Immunol. 2012 Aug;24(4):507-11. doi: 10.1016/j.coi.2012.04.002. Epub 2012 Apr 27.
9
Influenza virus H1N1pdm09 infections in the young and old: evidence of greater antibody diversity and affinity for the hemagglutinin globular head domain (HA1 Domain) in the elderly than in young adults and children.老年人与年轻人中的 H1N1pdm09 流感病毒感染：老年人比年轻人和儿童的血凝素球形头部结构域（HA1 结构域）具有更高的抗体多样性和亲和力的证据。
J Virol. 2012 May;86(10):5515-22. doi: 10.1128/JVI.07085-11. Epub 2012 Feb 29.
10
The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.老年人未满足的需求：免疫衰老、CMV 感染、合并症和衰弱如何给更有效的流感疫苗的开发带来挑战。
Vaccine. 2012 Mar 9;30(12):2060-7. doi: 10.1016/j.vaccine.2012.01.015. Epub 2012 Jan 27.
Zotero 插件