LaRock Christopher N, Nizet Victor
Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Skaggs School of Medicine and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Rady Children's Hospital, San Diego, CA, USA.
Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3047-54. doi: 10.1016/j.bbamem.2015.02.010. Epub 2015 Feb 17.
Cationic antimicrobial peptides (CAMPs) are critical front line contributors to host defense against invasive bacterial infection. These immune factors have direct killing activity toward microbes, but many pathogens are able to resist their effects. Group A Streptococcus, group B Streptococcus and Streptococcus pneumoniae are among the most common pathogens of humans and display a variety of phenotypic adaptations to resist CAMPs. Common themes of CAMP resistance mechanisms among the pathogenic streptococci are repulsion, sequestration, export, and destruction. Each pathogen has a different array of CAMP-resistant mechanisms, with invasive disease potential reflecting the utilization of several mechanisms that may act in synergy. Here we discuss recent progress in identifying the sources of CAMP resistance in the medically important Streptococcus genus. Further study of these mechanisms can contribute to our understanding of streptococcal pathogenesis, and may provide new therapeutic targets for therapy and disease prevention. This article is part of a Special Issue entitled: Bacterial Resistance to Antimicrobial Peptides.
阳离子抗菌肽（CAMP）是宿主抵御侵袭性细菌感染的关键一线防御因子。这些免疫因子对微生物具有直接杀伤活性，但许多病原体能够抵抗其作用。A组链球菌、B组链球菌和肺炎链球菌是人类最常见的病原体，它们表现出多种表型适应性以抵抗CAMP。致病性链球菌中CAMP抗性机制的共同主题包括排斥、隔离、输出和破坏。每种病原体都有不同的CAMP抗性机制组合，侵袭性疾病的潜力反映了可能协同作用的几种机制的利用情况。在此，我们讨论了在确定医学上重要的链球菌属中CAMP抗性来源方面的最新进展。对这些机制的进一步研究有助于我们理解链球菌的发病机制，并可能为治疗和疾病预防提供新的治疗靶点。本文是名为“细菌对抗菌肽的抗性”的特刊的一部分。
