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IL-31 Induces Chemotaxis, Calcium Mobilization, Release of Reactive Oxygen Species, and CCL26 in Eosinophils, Which Are Capable to Release IL-31.

作者信息

Kunsleben Nikola, Rüdrich Urda, Gehring Manuela, Novak Natalija, Kapp Alexander, Raap Ulrike

机构信息

Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.

出版信息

J Invest Dermatol. 2015 Jul;135(7):1908-1911. doi: 10.1038/jid.2015.106. Epub 2015 Mar 19.

DOI:10.1038/jid.2015.106
PMID:25789701
Abstract
摘要

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IL-31 Induces Chemotaxis, Calcium Mobilization, Release of Reactive Oxygen Species, and CCL26 in Eosinophils, Which Are Capable to Release IL-31.白细胞介素-31可诱导嗜酸性粒细胞发生趋化作用、钙动员、活性氧释放及CCL26释放，而嗜酸性粒细胞能够释放白细胞介素-31。
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A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.一种感觉神经元表达的白细胞介素-31 受体介导 T 辅助细胞依赖性瘙痒：涉及 TRPV1 和 TRPA1。
J Allergy Clin Immunol. 2014 Feb;133(2):448-60. doi: 10.1016/j.jaci.2013.10.048. Epub 2013 Dec 25.
2
Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation.人白细胞介素-31 由白细胞介素-4 诱导，并促进 TH2 驱动的炎症。
J Allergy Clin Immunol. 2013 Aug;132(2):446-54.e5. doi: 10.1016/j.jaci.2013.03.050. Epub 2013 May 18.
3
IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis.
大疱性类天疱疮的病理生理学：2 型炎症的作用和新兴治疗策略（叙述性评论）。
Adv Ther. 2024 Dec;41(12):4418-4432. doi: 10.1007/s12325-024-02992-w. Epub 2024 Oct 19.
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Eosinophil extracellular vesicles and DNA traps in allergic inflammation.嗜酸性粒细胞胞外囊泡与变应性炎症中的DNA陷阱
Front Allergy. 2024 Aug 1;5:1448007. doi: 10.3389/falgy.2024.1448007. eCollection 2024.
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The Central Roles of Keratinocytes in Coordinating Skin Immunity.角质形成细胞在皮肤免疫协调中的核心作用。
J Invest Dermatol. 2024 Nov;144(11):2377-2398. doi: 10.1016/j.jid.2024.06.1280. Epub 2024 Aug 8.
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Characterization of cells and mediators associated with pruritus in primary cutaneous T-cell lymphomas.描述原发性皮肤 T 细胞淋巴瘤中与瘙痒相关的细胞和介质。
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Int J Mol Sci. 2024 Feb 5;25(3):1922. doi: 10.3390/ijms25031922.
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J Inflamm Res. 2023 Aug 23;16:3643-3653. doi: 10.2147/JIR.S423131. eCollection 2023.
白细胞介素-31 与特应性皮炎患儿的疾病活动度和 Th2 细胞因子水平显著相关。
Pediatr Allergy Immunol. 2012 May;23(3):285-8. doi: 10.1111/j.1399-3038.2011.01241.x.
4
Signaling by IL-31 and functional consequences.IL-31 的信号转导及其功能后果。
Eur J Cell Biol. 2012 Jun-Jul;91(6-7):552-66. doi: 10.1016/j.ejcb.2011.07.006. Epub 2011 Oct 5.
5
Ultraviolet B radiation and reactive oxygen species modulate interleukin-31 expression in T lymphocytes, monocytes and dendritic cells.中波紫外线辐射和活性氧物质调节 T 淋巴细胞、单核细胞和树突状细胞中白细胞介素-31 的表达。
Br J Dermatol. 2011 Nov;165(5):966-75. doi: 10.1111/j.1365-2133.2011.10487.x. Epub 2011 Oct 17.
6
Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis.Th2 细胞因子 IL-31 激活人嗜酸性粒细胞和表皮角质形成细胞：特应性皮炎发病机制的启示。
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Functional extracellular eosinophil granules: novel implications in eosinophil immunobiology.功能性细胞外嗜酸性粒细胞颗粒：嗜酸性粒细胞免疫生物学的新启示
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Correlation of IL-31 serum levels with severity of atopic dermatitis.白细胞介素-31血清水平与特应性皮炎严重程度的相关性。
J Allergy Clin Immunol. 2008 Aug;122(2):421-3. doi: 10.1016/j.jaci.2008.05.047.
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A new paradigm of eosinophil granulocytes: neuroimmune interactions.嗜酸性粒细胞的新范式：神经免疫相互作用。
Exp Dermatol. 2008 Sep;17(9):731-8. doi: 10.1111/j.1600-0625.2008.00741.x. Epub 2008 May 26.
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Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis.在特应性皮炎和过敏性接触性皮炎中，IL-31表达水平的升高与IL-4和IL-13相关。
J Allergy Clin Immunol. 2006 Oct;118(4):930-7. doi: 10.1016/j.jaci.2006.07.015. Epub 2006 Sep 1.