Ahanchian Hamid, Nouri Zahra, Jafari Seyed-Ali, Moghiman Toktam, Amirian Mohammad-Hadi, Ezzati Atefeh, Kianifar Hamid-Reza
Department of Pediatric Allergy and Immunology.
Research Development Center, Ghaem hospital.
Iran J Pediatr. 2014 Feb;24(1):29-34. Epub 2014 Jan 3.
Cows milk protein allergy usually occurs in infants within the first months of life. It can affect several organs, but gastrointestinal symptoms are the most clinical symptoms observed. The most effective treatment is restricting the cow s milk protein in mother and infant`s diet. Lactobacillus GG supplementation in infant could be effective through modulation of the immune system and the gut microflora.
Thirty two breastfed infants with cows milk protein allergy were enrolled in a double-blinded randomized controlled trial in which they received Synbiotic (n=16) or placebo (n=16) once a day for one month, simultaneously with cows milk protein restriction in mother and infant`s diet. Clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding and diarrhea), head circumference, body length and weight were recorded at the beginning, the end of the first and third month of study. Findings : Percentage of increment in head circumference and weight were statistically more in synbiotic group compared with placebo group at the end of the first and third month of study. There was no significant difference in resolution of clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding or diarrhea) and percentage of increment in body length.
Synbiotic supplementation in infants may improve increment of head circumference and weight gain, but has no effect on resolution of clinical symptoms.
牛奶蛋白过敏通常发生在出生后最初几个月的婴儿中。它可影响多个器官，但胃肠道症状是最常见的临床症状。最有效的治疗方法是在母婴饮食中限制牛奶蛋白。婴儿补充鼠李糖乳杆菌GG可能通过调节免疫系统和肠道微生物群而有效。
32名患有牛奶蛋白过敏的母乳喂养婴儿参加了一项双盲随机对照试验，他们每天接受一次合生元（n = 16）或安慰剂（n = 16），持续一个月，同时在母婴饮食中限制牛奶蛋白。在研究开始时、第一个月末和第三个月末记录临床胃肠道症状（呕吐、绞痛、直肠出血和腹泻）、头围、身长和体重。结果：在研究的第一个月末和第三个月末，合生元组的头围和体重增加百分比在统计学上高于安慰剂组。临床胃肠道症状（呕吐、绞痛、直肠出血或腹泻）的缓解以及身长增加百分比没有显著差异。
婴儿补充合生元可能会改善头围增加和体重增长，但对临床症状的缓解没有影响。
