Arifler Dizem, Zhu Tingting, Madaan Sara, Tachtsidis Ilias
Physics Group, Middle East Technical University, Northern Cyprus Campus, Kalkanli, via Mersin 10 Turkey.
Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK.
Biomed Opt Express. 2015 Feb 23;6(3):933-47. doi: 10.1364/BOE.6.000933. eCollection 2015 Mar 1.
We analyze broadband near-infrared spectroscopic measurements obtained from newborn piglets subjected to hypoxia-ischemia and we aim to identify optimal wavelength combinations for monitoring cerebral tissue chromophores. We implement an optimization routine based on the genetic algorithm to perform a heuristic search for discrete wavelength combinations that can provide accurate concentration information when benchmarked against the gold standard of 121 wavelengths. The results indicate that it is possible to significantly reduce the number of measurement wavelengths used in conjunction with spectroscopic algorithms and still achieve a high performance in estimating changes in concentrations of oxyhemoglobin, deoxyhemoglobin, and oxidized cytochrome c oxidase. While the use of a 3-wavelength combination leads to mean recovery errors of up to 10%, these errors drop to less than 4% with 4 or 5 wavelengths and to even less than 2% with 8 wavelengths.
我们分析了从经历缺氧缺血的新生仔猪获得的宽带近红外光谱测量数据，旨在确定用于监测脑组织发色团的最佳波长组合。我们基于遗传算法实施了一种优化程序，以对离散波长组合进行启发式搜索，当以121个波长的金标准为基准时，这些组合能够提供准确的浓度信息。结果表明，结合光谱算法使用的测量波长数量有可能显著减少，并且在估计氧合血红蛋白、脱氧血红蛋白和氧化细胞色素c氧化酶浓度变化方面仍能实现高性能。虽然使用3波长组合会导致平均恢复误差高达10%，但使用4或5个波长时这些误差降至4%以下，使用8个波长时甚至降至2%以下。
