Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China.
Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Biomaterials. 2015 Jun;52:407-16. doi: 10.1016/j.biomaterials.2015.02.054. Epub 2015 Mar 18.
Photothermal ablation (PTA) therapy has been viewed as an invasive option for cancer therapy with minimal deconstruction of healthy tissues. In this study, a potent candidate of (NH4)xWO3 nanocube was developed for PTA treatment of metastatic breast cancer in the second near-infrared (NIR) window. It was found that the as-synthesized (NH4)xWO3 nanocube had significant photoabsorption across the whole NIR window of 780-2500 nm and exhibited considerable photo-heat conversion efficiency. Moreover, the as-prepared (NH4)xWO3 nanocube displayed good biocompatibility and high cellular uptake efficiency through endocytosis pathway without nuclei entry. The PTA study employing 1064 nm laser in the second NIR window revealed that (NH4)xWO3 nanocubes induced significant cell necrosis and apoptosis by producing obviously hyperthermia effect inside cancer cells. Using an orthotopicly implanted breast tumor model, it demonstrated that the (NH4)xWO3 nanocube was a promising photothermal agent for effective ablation of solid tumors and suppressing their distant metastasis.
光热烧蚀（PTA）疗法被视为一种对癌症的有创治疗选择，对健康组织的破坏最小。在这项研究中，开发了一种（NH4）xWO3纳米立方体形貌的强效候选物，用于第二近红外（NIR）窗口中转移性乳腺癌的 PTA 治疗。研究发现，所合成的（NH4）xWO3纳米立方体形貌在整个 NIR 窗口 780-2500nm 范围内具有显著的光吸收，并表现出相当大的光热转换效率。此外，通过内吞作用途径，所制备的（NH4）xWO3纳米立方体形貌表现出良好的生物相容性和高细胞摄取效率，而不会进入细胞核。在第二近红外窗口中使用 1064nm 激光进行的 PTA 研究表明，（NH4）xWO3纳米立方体形貌通过在癌细胞内产生明显的过热效应，导致显著的细胞坏死和凋亡。使用原位植入的乳腺癌肿瘤模型，证明了（NH4）xWO3纳米立方体形貌是一种很有前途的光热剂，可有效消融实体瘤并抑制其远处转移。
