用于靶向给药的非球形颗粒。
Non-Spherical Particles for Targeted Drug Delivery.
作者信息
Chen Jinrong, Clay Nicholas, Kong Hyunjoon
机构信息
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana IL, 61801, USA.
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana IL, 61801, USA ; Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana IL, 61801, USA ; Department of Chemical Engineering, Soongsil University, Seoul, South Korea.
出版信息
Chem Eng Sci. 2015 Mar 24;125:20-24. doi: 10.1016/j.ces.2014.10.022.
Nano- and microparticles loaded with various bioimaging contrast agents or therapeutic molecules have been increasingly used for the diagnosis and treatment of diseases and tissue defects. These particles, often a filled or hollow sphere, can extend the lifetime of encapsulated biomedical modalities in circulation and in target tissue. However, there is a great need to improve the drug loading and targeting efficiency of these particles. Recently, several simulation and experimental studies reported that particle shape plays a pivotal role in the targeted delivery of molecules. To better understand these findings and subsequently expedite the use of particles in biomedical applications, this review paper summarizes the methods to prepare non-spherical nano- and micro-scaled particles. In addition, this review covers studies reporting the effects of particle shape on the loading, delivery and release of encapsulated bioactive cargos. Finally, it discusses future directions to further improve the properties of non-spherical particles.
负载各种生物成像造影剂或治疗分子的纳米和微粒已越来越多地用于疾病和组织缺陷的诊断与治疗。这些颗粒通常是实心或空心球体，可延长封装的生物医学制剂在循环系统和靶组织中的存留时间。然而，迫切需要提高这些颗粒的载药量和靶向效率。最近，一些模拟和实验研究报告称，颗粒形状在分子的靶向递送中起着关键作用。为了更好地理解这些发现并随后加快颗粒在生物医学应用中的使用，本文综述总结了制备非球形纳米和微米级颗粒的方法。此外，本综述涵盖了报道颗粒形状对封装的生物活性货物的负载、递送和释放影响的研究。最后，讨论了进一步改善非球形颗粒性能的未来方向。
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