Jadhav Santosh, Jadhav Abhijeet, Thopte Shameeka, Marathe Swati, Vhathakar Prakash, Chivte Pankaj, Jamkhande Amol
Assistant Professor, Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College & Hospital, Pune, Maharashtra, India.
Professor and Head, Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College & Hospital, Pune, Maharashtra, India.
J Int Oral Health. 2015 Mar;7(3):72-4.
Sjögren syndrome is chronic, systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. It is an elaborate involvement of the lacrimal and salivary glands, which eventually lead to keratoconjunctivitis sicca and xerostomia. It may occur in two forms - Primary and secondary, which is associated with another autoimmune disease, most commonly rheumatoid arthritis. Numerous criteria were proposed for diagnosis of Sjögren syndrome. Most widely accepted are American and European group developed international classification criteria for Sjögrens syndrome. These criteria include ocular symptoms, oral symptoms, ocular signs, histopathology, salivary gland involvement and sialography. The classification requires four of the six items, one of which must be positive minor salivary gland biopsy or a positive antibody test. Early diagnosis is important to prevent further complications. The aim of this paper is to emphasis on oral changes, advanced diagnosis, and management of Sjögren's syndrome.
干燥综合征是一种慢性全身性自身免疫性疾病，其特征是外分泌腺淋巴细胞浸润。它主要累及泪腺和唾液腺，最终导致干眼症和口干症。它可能以两种形式出现——原发性和继发性，继发性与另一种自身免疫性疾病相关，最常见的是类风湿性关节炎。已经提出了许多诊断干燥综合征的标准。最被广泛接受的是美国和欧洲组织制定的干燥综合征国际分类标准。这些标准包括眼部症状、口腔症状、眼部体征、组织病理学、唾液腺受累情况和唾液造影。分类需要六项中的四项，其中一项必须是小唾液腺活检阳性或抗体检测阳性。早期诊断对于预防进一步并发症很重要。本文的目的是强调干燥综合征的口腔变化、先进诊断方法和治疗。
