新型曲霉菌来源的倍半萜类化合物具有抑制环氧化酶-2 表达的作用。
New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression.
机构信息
†Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
‡Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
出版信息
Org Lett. 2015 May 15;17(10):2330-3. doi: 10.1021/acs.orglett.5b00739. Epub 2015 Apr 27.
Two novel meroterpenoids, yaminterritrems A (1) and B (2), were isolated from Aspergillus terreus collected from hot spring zones in Yang-Ming Mountain, Taiwan, and cultured at 40 °C. The structures of 1 and 2 were elucidated by NMR, MS spectral and X-ray crystallographic analyses. The biosynthetic route for 1 and 2 involving the conversion of the sesquiterpene with phenyl-α-pyrone is proposed. Besides, 2 exhibited a dose-dependent inhibitory effect on COX-2 expression in LPS-stimulated RAW264.7 macrophages.
从台湾阳明山温泉区采集的土曲霉（Aspergillus terreus）在 40°C 下培养，分离得到两个新的倍半萜类化合物yaminterritrems A（1）和 B（2）。通过 NMR、MS 谱和 X 射线晶体学分析阐明了 1 和 2 的结构。提出了 1 和 2 的生物合成途径，涉及到倍半萜与苯基-α-吡喃酮的转化。此外，2 对 LPS 刺激的 RAW264.7 巨噬细胞中 COX-2 表达具有剂量依赖性抑制作用。
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