Lasaite Lina, Spadiene Asta, Savickiene Nijole, Skesters Andrejs, Silova Alise
Nat Prod Commun. 2014 Sep;9(9):1345-50.
Interest in finding natural antioxidants for use in food or medical materials to prevent free radical imbalance has increased considerably over the past years. The aim of this research was to evaluate changes in glycemic control and psychological state of patients with type 2 diabetes mellitus (T2DM) after use of antioxidant plant preparations. Fifty-six patients with T2DM were randomly allocated to receive standardized Ginkgo biloba L. leaves dry extract, green tea dry extract, or placebo capsules. Diabetes glycemic control measured as glycated hemoglobin (HbA1c) level, antioxidant state and psychological data were evaluated at baseline, after 9 and 18 months of using either antioxidant preparations or placebo. The level of perceived stress lowered significantly after 9 months (p = 0.038) and 18 months (p = 0.030), and the psychological aspect of quality of life significantly improved after 18 months (p = 0.019) of use of G. biloba extrac. No significant differences were detected after using green tea extract. In patients using placebo, significant lowering of HbA1c level was observed after 18 months (p = 0.017). In conclusion, antioxidant G. biloba leaf extract exhibited a mild effect on psychological state and a trend of improving glycemic control in patients with type 2 diabetes mellitus.
在过去几年中，人们对寻找用于食品或医疗材料以预防自由基失衡的天然抗氧化剂的兴趣大幅增加。本研究的目的是评估2型糖尿病（T2DM）患者使用抗氧化植物制剂后血糖控制和心理状态的变化。56例T2DM患者被随机分配接受标准化银杏叶干提取物、绿茶干提取物或安慰剂胶囊。在使用抗氧化剂制剂或安慰剂的基线期、9个月和18个月后，评估以糖化血红蛋白（HbA1c）水平衡量的糖尿病血糖控制、抗氧化状态和心理数据。使用银杏叶提取物9个月（p = 0.038）和18个月（p = 0.030）后，感知压力水平显著降低，使用银杏叶提取物18个月（p = 0.019）后，生活质量的心理方面显著改善。使用绿茶提取物后未检测到显著差异。在使用安慰剂的患者中，18个月后观察到HbA1c水平显著降低（p = 0.017）。总之，抗氧化剂银杏叶提取物对2型糖尿病患者的心理状态有轻微影响，并具有改善血糖控制的趋势。
