Mallmann Eduardo José J, Cunha Francisco Afrânio, Castro Bruno N M F, Maciel Auberson Martins, Menezes Everardo Albuquerque, Fechine Pierre Basílio Almeida
Grupo de Química de Materiais Avançados, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Laboratório de Microbiologia de Leveduras, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Rev Inst Med Trop Sao Paulo. 2015 Mar-Apr;57(2):165-7. doi: 10.1590/S0036-46652015000200011.
Silver nanoparticles (AgNPs) are metal structures at the nanoscale. AgNPs have exhibited antimicrobial activities against fungi and bacteria; however synthesis of AgNPs can generate toxic waste during the reaction process. Accordingly, new routes using non-toxic compounds have been researched. The proposal of the present study was to synthesize AgNPs using ribose as a reducing agent and sodium dodecyl sulfate (SDS) as a stabilizer. The antifungal activity of these particles against C. albicans and C. tropicalis was also evaluated. Stable nanoparticles 12.5 ± 4.9 nm (mean ± SD) in size were obtained, which showed high activity against Candida spp. and could represent an alternative for fungal infection treatment.
银纳米颗粒（AgNPs）是纳米级的金属结构。AgNPs已表现出对真菌和细菌的抗菌活性；然而，AgNPs的合成在反应过程中会产生有毒废物。因此，人们研究了使用无毒化合物的新途径。本研究的提议是使用核糖作为还原剂和十二烷基硫酸钠（SDS）作为稳定剂来合成AgNPs。还评估了这些颗粒对白色念珠菌和热带念珠菌的抗真菌活性。获得了尺寸为12.5±4.9nm（平均值±标准差）的稳定纳米颗粒，其对念珠菌属表现出高活性，并且可以代表真菌感染治疗的一种替代方法。
