Craig Benjamin M, Greiner Wolfgang, Brown Derek S, Reeve Bryce B
Moffitt Cancer Center and University of South Florida, Tampa, FL, USA.
School of Public Health, University of Bielefeld, Bielefeld, Germany.
Health Econ. 2016 Jun;25(6):768-77. doi: 10.1002/hec.3184. Epub 2015 Apr 28.
Many economic analyses fail to incorporate evidence on child health-related quality of life because of a paucity of quality-adjusted life year (QALY) estimates. This health valuation study is the first to summarize the EQ-5D-Y on a QALY scale. Drawn from a nationally representative panel, 5207 adult respondents were asked to choose between two losses in child health-related quality of life. Based on their choices, a 1-year increase in child pain/discomfort from 'some' to 'a lot' equals a loss of 4 QALYs (95% CI, 3.8-4.4). Likewise, a 1-year increase in child anxiety/depression from 'a bit' to 'very worried, sad, or unhappy' equals a loss of 2 QALYs (95% CI, 1.9-2.2). These findings enable the integration of child-reported outcomes with adult preferences to inform economic analysis. Results inform both clinical practice and resource allocation decisions by enhancing understanding of difficult tradeoffs in child-reported outcomes. Copyright © 2015 John Wiley & Sons, Ltd.
由于缺乏质量调整生命年（QALY）估计值，许多经济分析未能纳入与儿童健康相关的生活质量证据。这项健康估值研究首次在QALY量表上总结了儿童版EQ-5D量表（EQ-5D-Y）。从一个具有全国代表性的样本中选取了5207名成年受访者，要求他们在两种与儿童健康相关的生活质量损失之间做出选择。根据他们的选择，儿童疼痛/不适从“有些”增加到“很多”持续1年相当于损失4个QALY（95%置信区间，3.8 - 4.4）。同样，儿童焦虑/抑郁从“有点”增加到“非常担心、悲伤或不开心”持续1年相当于损失2个QALY（95%置信区间，1.9 - 2.2）。这些发现能够将儿童报告的结果与成人偏好相结合，为经济分析提供参考。通过加强对儿童报告结果中艰难权衡的理解，研究结果为临床实践和资源分配决策提供了依据。版权所有© 2015约翰威立父子有限公司。
