Department of Microbiology and Immunology, Emory University, Atlanta, GA 30329, USA ; Yerkes Primate Research Center, Emory University, Atlanta, GA 30329, USA ; Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA.
Yerkes Primate Research Center, Emory University, Atlanta, GA 30329, USA ; Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA ; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.
Antibiotics (Basel). 2015 Mar;4(1):18-41. doi: 10.3390/antibiotics4010018.
Cationic antimicrobial peptides (CAMPs) are important innate immune defenses that inhibit colonization by pathogens and contribute to clearance of infections. Gram-negative bacterial pathogens are a major target, yet many of them have evolved mechanisms to resist these antimicrobials. These resistance mechanisms can be critical contributors to bacterial virulence and are often crucial for survival within the host. Here, we summarize methods used by Gram-negative bacteria to resist CAMPs. Understanding these mechanisms may lead to new therapeutic strategies against pathogens with extensive CAMP resistance.
阳离子抗菌肽 (CAMPs) 是重要的先天免疫防御机制，可抑制病原体定植并有助于清除感染。革兰氏阴性细菌病原体是主要目标，但其中许多病原体已经进化出抵抗这些抗菌药物的机制。这些耐药机制可能是细菌毒力的重要贡献者，并且通常对于宿主内的存活至关重要。在这里，我们总结了革兰氏阴性细菌抵抗 CAMPs 的方法。了解这些机制可能会为具有广泛 CAMP 耐药性的病原体带来新的治疗策略。
