叙利亚乳腺癌女性中爱泼斯坦-巴尔病毒的发病率：一项组织芯片研究。
Incidence of Epstein-Barr virus in Syrian women with breast cancer: A tissue microarray study.
作者信息
Aboulkassim Tahar, Yasmeen Amber, Akil Nizar, Batist Gerald, Al Moustafa Ala-Eddin
机构信息
a Segal Cancer Center ; Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital ; McGill University ; Montreal , Quebec , Canada.
出版信息
Hum Vaccin Immunother. 2015;11(4):951-5. doi: 10.1080/21645515.2015.1009342.
Abstract
Epstein-Barr virus (EBV) has been recently shown to be present in human breast cancer worldwide, which could play an important role in the initiation and progression of this cancer. In this regard, we aimed to explore the prevalence of EBV in 108 breast cancer tissues from Syrian women using polymerase chain reaction (PCR) and tissue microarray (TMA) analysis. We found that EBV is present in 56 (51.85%) of breast cancers samples. Additionally, we report that the expression of LMP1 gene of EBV is associated with a cancer invasive phenotype in the majority of the cancer samples. These data imply that EBV is present in breast cancer worldwide including Syria and its presence is associated with more aggressive cancer phenotype. Thus, future investigations are needed to elucidate the exact role of EBV in breast carcinogenesis and metastasis.
摘要
最近研究表明，爱泼斯坦-巴尔病毒（EBV）在全球范围内的人类乳腺癌组织中均有存在，其可能在该癌症的发生和发展过程中发挥重要作用。鉴于此，我们旨在通过聚合酶链反应（PCR）和组织芯片（TMA）分析，探究叙利亚女性108份乳腺癌组织中EBV的流行情况。我们发现，56份（51.85%）乳腺癌样本中存在EBV。此外，我们报告称，在大多数癌症样本中，EBV的潜伏膜蛋白1（LMP1）基因表达与癌症侵袭表型相关。这些数据表明，包括叙利亚在内，全球范围内的乳腺癌组织中均存在EBV，且其存在与更具侵袭性的癌症表型相关。因此，需要进一步研究以阐明EBV在乳腺癌发生和转移过程中的确切作用。
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