Al Moustafa Ala-Eddin, Al-Antary Noor, Aboulkassim Tahar, Akil Nizar, Batist Gerald, Yasmeen Amber
a College of Medicine & Biomedical Research Centre, Qatar University , Doha , Qatar.
b Oncology Department , McGill University , Montreal , Quebec , Canada.
Hum Vaccin Immunother. 2016 Jul 2;12(7):1936-9. doi: 10.1080/21645515.2016.1139255. Epub 2016 Apr 15.
ABSTRAT We recently performed 2 studies viewing the presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human breast cancer in the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in breast cancer in Syrian women. Therefore, and based on our previous studies and present data, we reveal that 35 (32%) of 108 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high grade invasive ductal carcinomas (IDCs) with at least one positive lymph nodes, in comparison with EBV and high-risk HPVs-positive samples, which are low to intermediate grade IDCs, respectively. Future studies are needed to confirm the co-presence and the cooperation effect of these onco-viruses in human breast carcinogenesis and metastasis.
摘要 我们最近进行了两项研究，观察叙利亚人群乳腺癌中爱泼斯坦-巴尔病毒（EBV）以及高危人乳头瘤病毒（HPV）16、18、31、33和35型的存在情况。在此，我们报告EBV和高危HPV在叙利亚女性乳腺癌中共同存在。因此，基于我们之前的研究和当前数据，我们发现108个癌症样本中有35个（32%）EBV和高危HPV均呈阳性，与分别为低至中度浸润性导管癌（IDC）的EBV和高危HPV阳性样本相比，它们的共同存在与至少有一个阳性淋巴结的高级别浸润性导管癌相关。未来需要开展研究来证实这些致癌病毒在人类乳腺癌发生和转移中的共同存在及协同作用。
