微流控阻抗流式细胞术可实现高通量单细胞电学特性表征。
Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization.
作者信息
Chen Jian, Xue Chengcheng, Zhao Yang, Chen Deyong, Wu Min-Hsien, Wang Junbo
机构信息
State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China.
Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 333, Taiwan.
出版信息
Int J Mol Sci. 2015 Apr 29;16(5):9804-30. doi: 10.3390/ijms16059804.
This article reviews recent developments in microfluidic impedance flow cytometry for high-throughput electrical property characterization of single cells. Four major perspectives of microfluidic impedance flow cytometry for single-cell characterization are included in this review: (1) early developments of microfluidic impedance flow cytometry for single-cell electrical property characterization; (2) microfluidic impedance flow cytometry with enhanced sensitivity; (3) microfluidic impedance and optical flow cytometry for single-cell analysis and (4) integrated point of care system based on microfluidic impedance flow cytometry. We examine the advantages and limitations of each technique and discuss future research opportunities from the perspectives of both technical innovation and clinical applications.
本文综述了用于单细胞高通量电学特性表征的微流控阻抗流式细胞术的最新进展。本综述涵盖了微流控阻抗流式细胞术用于单细胞表征的四个主要方面：（1）用于单细胞电学特性表征的微流控阻抗流式细胞术的早期发展；（2）具有增强灵敏度的微流控阻抗流式细胞术；（3）用于单细胞分析的微流控阻抗和光学流式细胞术；以及（4）基于微流控阻抗流式细胞术的即时护理集成系统。我们研究了每种技术的优缺点，并从技术创新和临床应用的角度讨论了未来的研究机会。
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