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对登革热预防中病媒控制的批判性评估。

A critical assessment of vector control for dengue prevention.

作者信息

Achee Nicole L, Gould Fred, Perkins T Alex, Reiner Robert C, Morrison Amy C, Ritchie Scott A, Gubler Duane J, Teyssou Remy, Scott Thomas W

机构信息

Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, United States of America.

Department of Entomology, North Carolina State University, Raleigh, North Carolina, United States of America.

出版信息

PLoS Negl Trop Dis. 2015 May 7;9(5):e0003655. doi: 10.1371/journal.pntd.0003655. eCollection 2015 May.

Abstract

Recently, the Vaccines to Vaccinate (v2V) initiative was reconfigured into the Partnership for Dengue Control (PDC), a multi-sponsored and independent initiative. This redirection is consistent with the growing consensus among the dengue-prevention community that no single intervention will be sufficient to control dengue disease. The PDC's expectation is that when an effective dengue virus (DENV) vaccine is commercially available, the public health community will continue to rely on vector control because the two strategies complement and enhance one another. Although the concept of integrated intervention for dengue prevention is gaining increasingly broader acceptance, to date, no consensus has been reached regarding the details of how and what combination of approaches can be most effectively implemented to manage disease. To fill that gap, the PDC proposed a three step process: (1) a critical assessment of current vector control tools and those under development, (2) outlining a research agenda for determining, in a definitive way, what existing tools work best, and (3) determining how to combine the best vector control options, which have systematically been defined in this process, with DENV vaccines. To address the first step, the PDC convened a meeting of international experts during November 2013 in Washington, DC, to critically assess existing vector control interventions and tools under development. This report summarizes those deliberations.

摘要

最近,“疫苗接种促进疫苗接种”(v2V)倡议被重新组建为登革热控制伙伴关系(PDC),这是一项多方赞助的独立倡议。这一转向与登革热预防领域日益形成的共识相一致,即单一干预措施不足以控制登革热疾病。PDC预计,当有效的登革热病毒(DENV)疫苗上市时,公共卫生界将继续依赖病媒控制,因为这两种策略相辅相成。尽管登革热预防综合干预的概念越来越被广泛接受,但迄今为止,对于如何以及采用何种方法组合能够最有效地控制疾病的细节尚未达成共识。为填补这一空白,PDC提出了一个三步流程:(1)对当前的病媒控制工具和正在研发的工具进行批判性评估;(2)勾勒出一个研究议程,以明确确定哪些现有工具效果最佳;(3)确定如何将在此过程中系统定义的最佳病媒控制选项与DENV疫苗相结合。为完成第一步,PDC于2013年11月在华盛顿特区召开了一次国际专家会议,以批判性评估现有的病媒控制干预措施和正在研发的工具。本报告总结了这些讨论内容。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926e/4423954/7cfe4ceb0f4d/pntd.0003655.g001.jpg

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