Kim Mu-Hyon, Park Kyeongsoon, Choi Kyung-Hee, Kim Soo-Hong, Kim Se Eun, Jeong Chang-Mo, Huh Jung-Bo
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Korea.
Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea.
Int J Mol Sci. 2015 May 6;16(5):10324-36. doi: 10.3390/ijms160510324.
The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigate its osseointegration characteristics in vivo. Four different types of Ti implants were examined, that is, machined Ti (control), SLA, anodized, and Modi-ANO Ti. In the cell adhesion study, Modi-ANO Ti showed higher initial MG-63 cell adhesion and induced greater filopodia growth than other groups. In vivo study in a beagle model revealed the bone-to-implant contact (BIC) of Modi-ANO Ti (74.20%±10.89%) was much greater than those of machined (33.58%±8.63%), SLA (58.47%±12.89), or ANO Ti (59.62%±18.30%). In conclusion, this study demonstrates that Modi-ANO Ti implants produced by sandblasting, acid etching, and anodizing improve cell adhesion and bone ongrowth as compared with machined, SLA, or ANO Ti implants. These findings suggest that the application of Modi-ANO surface treatment could improve the osseointegration of dental implant.
作者将一种新型钛（Ti）植入物描述为改良阳极氧化（ANO）Ti植入物，其表面经过喷砂、酸蚀（SLA）和阳极氧化技术处理。本研究的目的是在体外评估MG-63细胞对经改良ANO表面处理的Ti的粘附性，并在体内研究其骨整合特性。研究了四种不同类型的Ti植入物，即机械加工Ti（对照）、SLA、阳极氧化Ti和改良ANO Ti。在细胞粘附研究中，改良ANO Ti显示出比其他组更高的初始MG-63细胞粘附性，并诱导出更大的丝状伪足生长。在比格犬模型中的体内研究表明，改良ANO Ti的骨-植入物接触（BIC）（74.20%±10.89%）远高于机械加工Ti（33.58%±8.63%）、SLA（58.47%±12.89）或ANO Ti（59.62%±18.30%）。总之，本研究表明，与机械加工、SLA或ANO Ti植入物相比，通过喷砂、酸蚀和阳极氧化生产的改良ANO Ti植入物可改善细胞粘附和骨生长。这些发现表明，改良ANO表面处理的应用可以改善牙种植体的骨整合。
