Bourke S J, Carter R, Anderson K, Boyd J, King S, Douglas B, Boyd G
Department of Respiratory Medicine, Royal Infirmary, Glasgow, U.K.
Clin Exp Allergy. 1989 Nov;19(6):629-32. doi: 10.1111/j.1365-2222.1989.tb02758.x.
The aim of the study was to assess the degree of airways involvement in non-smoking subjects with extrinsic allergic alveolitis resulting from pigeon-derived antigens. Two hundred and eight pigeon fanciers completed a questionnaire of symptoms, performed spirometry on a Vitalograph Compact spirometer and had IgG antibody to pigeon gamma-globulin measured. Eighty fanciers had the acute form of pigeon fanciers' lung (PFL) and these subjects were less likely to be current smokers (P less than 0.001). Subjects with PFL had a higher prevalence of chronic bronchitis (P less than 0.001), large airways (P = 0.014) and peripheral airways obstruction (P less than 0.001). The prevalence of chronic bronchitis and peripheral airways obstruction increased significantly as the level of antibody to pigeon gamma-globulin rose. Peripheral airways obstruction, as manifest by a reduced FEF25-75%, was the most common abnormality found. Airways disease is an important feature of the acute form of PFL and consists of a hypersecretory disorder in the form of chronic bronchitis and of obstructive airways disease particularly affecting the peripheral airways.
本研究的目的是评估因鸽源抗原导致的外源性过敏性肺泡炎的非吸烟受试者的气道受累程度。208名信鸽爱好者完成了症状问卷，使用伟康紧凑型肺功能仪进行了肺功能测定，并检测了针对鸽γ球蛋白的IgG抗体。80名爱好者患有急性鸽友型肺（PFL），这些受试者当前吸烟的可能性较小（P<0.001）。PFL受试者慢性支气管炎（P<0.001）、大气道（P=0.014）和外周气道阻塞（P<0.001）的患病率更高。随着针对鸽γ球蛋白抗体水平的升高，慢性支气管炎和外周气道阻塞的患病率显著增加。以FEF25-75%降低为表现的外周气道阻塞是最常见的异常情况。气道疾病是急性PFL的一个重要特征，包括以慢性支气管炎形式出现的高分泌性疾病和尤其影响外周气道的阻塞性气道疾病。
