Rajappa Medha, Goswami Binita, Balasubramanian A, Chakraborty Baidarbhi, Kumar S
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
Department of Biochemistry, Lady Hardinge Medical College and Associated Hospitals, New Delhi, 110001 India.
Indian J Clin Biochem. 2015 Jul;30(3):281-5. doi: 10.1007/s12291-014-0438-0. Epub 2014 May 25.
Coronary artery disease (CAD) is a global epidemic currently. This study was planned to evaluate markers of inflammation and hemostasis and their possible association, if any, in patients with CAD. The study was carried out in 60 patients with acute myocardial infarction (AMI) and 60 age and gender matched controls. The following parameters were assayed in all study subjects-inflammatory-interleukin (IL)-10, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-α, fibrinogen; hemostatic-fibrinogen, fibrin D-dimer and a novel risk factor-homocysteine. Inflammatory markers (hs-CRP, TNF-α and IL-10), fibrinogen, fibrin D-dimer and homocysteine levels were significantly higher in the patients with AMI, as compared with controls. A positive correlation was observed between D-dimer and the inflammatory markers-hs-CRP and TNF-α. Upon multivariate analysis, TNF-α emerged as the best determinant of CAD in our study. Our results indicate that there is a possible interplay of inflammation and hemostasis in CAD, underlining their synergistic role in the pathogenesis of CAD.
冠状动脉疾病（CAD）目前是一种全球性流行病。本研究旨在评估CAD患者炎症和止血标志物及其可能存在的关联（若有）。该研究对60例急性心肌梗死（AMI）患者以及60例年龄和性别匹配的对照者进行。对所有研究对象检测了以下参数：炎症指标——白细胞介素（IL）-10、高敏C反应蛋白（hs-CRP）、肿瘤坏死因子（TNF）-α、纤维蛋白原；止血指标——纤维蛋白原、纤维蛋白D-二聚体以及一种新的危险因素——同型半胱氨酸。与对照组相比，AMI患者的炎症标志物（hs-CRP、TNF-α和IL-10）、纤维蛋白原、纤维蛋白D-二聚体和同型半胱氨酸水平显著更高。观察到D-二聚体与炎症标志物hs-CRP和TNF-α之间存在正相关。多因素分析显示，TNF-α是我们研究中CAD的最佳决定因素。我们的结果表明，CAD中炎症与止血之间可能存在相互作用，突显了它们在CAD发病机制中的协同作用。
