Ma Jian, Zhang Hong-Mei, Zhang Li-Wang, Zheng Min-Wen, Yu Min
Department of Research, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.
Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
Oncol Lett. 2015 Jun;9(6):2667-2669. doi: 10.3892/ol.2015.3103. Epub 2015 Apr 8.
Liposarcoma has previously been described in Western studies, however, such cases are rarely reported in the mediastinum. In addition, the presence of a liposarcoma with smooth muscle and neural differentiation has not been previously reported. Thus, the present study describes the rare case of a 28-year-old Chinese male admitted to our hospital with the symptoms of chest tightness and shortness of breath due to a recurrent fibrolipoma in the mediastinum. The resected tumor measured 23 cm at its largest diameter, with histopathological and immunohistochemical features indicating a well-differentiated liposarcoma accompanied by smooth muscle and neural differentiation. Following the resection, the patient underwent radiation treatment and remains alive with no evidence of disease recurrence at two months post-surgery. To the best of our knowledge, the present study is the first to report a case of liposarcoma with smooth muscle and neural differentiation, which indicates that liposarcomas could potentially originate from stem cells. The present study highlights the fact that pathologists must carefully investigate the histopathological characteristics of liposarcomas in order to obtain an accurate diagnosis.
脂肪肉瘤在西方研究中已有描述，然而，此类病例在纵隔中鲜有报道。此外，此前尚未报道过伴有平滑肌和神经分化的脂肪肉瘤。因此，本研究描述了一例罕见病例，一名28岁中国男性因纵隔复发性纤维脂肪瘤出现胸闷和气短症状入住我院。切除的肿瘤最大直径为23厘米，组织病理学和免疫组化特征表明为高分化脂肪肉瘤，伴有平滑肌和神经分化。切除术后，患者接受了放射治疗，术后两个月仍存活，无疾病复发迹象。据我们所知，本研究首次报道了一例伴有平滑肌和神经分化的脂肪肉瘤病例，这表明脂肪肉瘤可能起源于干细胞。本研究强调了病理学家必须仔细研究脂肪肉瘤的组织病理学特征以获得准确诊断这一事实。
