• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于N-巯基的硫化氢供体的设计、合成及心脏保护作用

Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors.

作者信息

Zhao Yu, Yang Chuntao, Organ Chelsea, Li Zhen, Bhushan Shashi, Otsuka Hiro, Pacheco Armando, Kang Jianming, Aguilar Hector C, Lefer David J, Xian Ming

机构信息

Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.

Department of Physiology, Guangzhou Medical University , Guangzhou 511436, China.

出版信息

J Med Chem. 2015 Sep 24;58(18):7501-11. doi: 10.1021/acs.jmedchem.5b01033. Epub 2015 Sep 4.

DOI:10.1021/acs.jmedchem.5b01033
PMID:26317692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4766970/
Abstract

Hydrogen sulfide (H2S) is a signaling molecule which plays regulatory roles in many physiological and/or pathological processes. Therefore, regulation of H2S levels could have great potential therapeutic value. In this work, we report the design, synthesis, and evaluation of a class of N-mercapto (N-SH)-based H2S donors. Thirty-three donors were synthesized and tested. Our results indicated that controllable H2S release from these donors could be achieved upon structural modifications. Selected donors (NSHD-1, NSHD-2, and NSHD-6) were tested in cellular models of oxidative damage and showed significant cytoprotective effects. Moreover, NSHD-1 and NSHD-2 were also found to exhibit potent protective effects in a murine model of myocardial ischemia reperfusion (MI/R) injury.

摘要

硫化氢（H₂S）是一种信号分子，在许多生理和/或病理过程中发挥调节作用。因此，调节H₂S水平可能具有巨大的潜在治疗价值。在这项工作中，我们报告了一类基于N-巯基（N-SH）的H₂S供体的设计、合成和评估。合成并测试了33种供体。我们的结果表明，通过结构修饰可以实现这些供体可控的H₂S释放。选择的供体（NSHD-1、NSHD-2和NSHD-6）在氧化损伤的细胞模型中进行了测试，并显示出显著的细胞保护作用。此外，还发现NSHD-1和NSHD-2在心肌缺血再灌注（MI/R）损伤的小鼠模型中表现出强大的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/77f536b03efb/jm-2015-010333_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/0b658358cdc8/jm-2015-010333_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/d5efd42ca4e8/jm-2015-010333_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/b4988901bef7/jm-2015-010333_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/b80f90c7b35a/jm-2015-010333_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/0b145018542c/jm-2015-010333_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/7a19a00605e9/jm-2015-010333_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/716f9b226bef/jm-2015-010333_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/c2bb536737cc/jm-2015-010333_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/138d5835b1da/jm-2015-010333_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/686d6f1dcf8a/jm-2015-010333_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/8785ec4380d6/jm-2015-010333_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/77f536b03efb/jm-2015-010333_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/0b658358cdc8/jm-2015-010333_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/d5efd42ca4e8/jm-2015-010333_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/b4988901bef7/jm-2015-010333_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/b80f90c7b35a/jm-2015-010333_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/0b145018542c/jm-2015-010333_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/7a19a00605e9/jm-2015-010333_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/716f9b226bef/jm-2015-010333_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/c2bb536737cc/jm-2015-010333_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/138d5835b1da/jm-2015-010333_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/686d6f1dcf8a/jm-2015-010333_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/8785ec4380d6/jm-2015-010333_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04d9/4766970/77f536b03efb/jm-2015-010333_0010.jpg

相似文献

1
Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors.基于N-巯基的硫化氢供体的设计、合成及心脏保护作用
J Med Chem. 2015 Sep 24;58(18):7501-11. doi: 10.1021/acs.jmedchem.5b01033. Epub 2015 Sep 4.
2
Controllable thioester-based hydrogen sulfide slow-releasing donors as cardioprotective agents.可控硫酯型硫化氢缓控释供体作为心脏保护剂。
Chem Commun (Camb). 2019 May 28;55(44):6193-6196. doi: 10.1039/c9cc02829c.
3
pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury.pH 控制的硫化氢释放治疗心肌缺血再灌注损伤。
J Am Chem Soc. 2016 May 25;138(20):6336-9. doi: 10.1021/jacs.6b01373. Epub 2016 May 17.
4
Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.可控硫化氢供体及其对心肌缺血再灌注损伤的作用。
ACS Chem Biol. 2013;8(6):1283-90. doi: 10.1021/cb400090d. Epub 2013 Apr 16.
5
The cardioprotective potential of hydrogen sulfide in myocardial ischemia/reperfusion injury (review).硫化氢在心肌缺血/再灌注损伤中的心脏保护潜力（综述）
Acta Physiol Hung. 2011 Dec;98(4):369-81. doi: 10.1556/APhysiol.98.2011.4.1.
6
The Role of Hydrogen Sulfide and H2S-donors in Myocardial Protection Against Ischemia/Reperfusion Injury.硫化氢和 H2S 供体在心肌缺血/再灌注损伤保护中的作用。
Curr Med Chem. 2018;25(34):4380-4401. doi: 10.2174/0929867325666180212120504.
7
Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent Mechanisms.硫化氢供体的心脏保护作用：依赖一氧化氮和不依赖一氧化氮的机制
J Pharmacol Exp Ther. 2016 Sep;358(3):431-40. doi: 10.1124/jpet.116.235119. Epub 2016 Jun 24.
8
Design and synthesis of polymeric hydrogen sulfide donors.聚合物硫化氢供体的设计与合成。
Bioconjug Chem. 2014 Jul 16;25(7):1290-300. doi: 10.1021/bc500150s. Epub 2014 Jul 1.
9
A novel controllable hydrogen sulfide-releasing molecule protects human skin keratinocytes against methylglyoxal-induced injury and dysfunction.一种新型可控硫化氢释放分子可保护人皮肤角质形成细胞免受甲基乙二醛诱导的损伤和功能障碍。
Cell Physiol Biochem. 2014;34(4):1304-17. doi: 10.1159/000366339. Epub 2014 Sep 29.
10
The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.硫化氢的产生可限制心肌缺血及再灌注损伤，并有助于内毒素预处理的心脏保护作用，但对大鼠的缺血无此作用。
Shock. 2006 Aug;26(2):154-61. doi: 10.1097/01.shk.0000225722.56681.64.

引用本文的文献

1
Protective Role of HS in High Glucose-Induced Cardiomyocyte and Endothelial Cell Dysfunction: A Mechanistic Review.硫酸乙酰肝素在高糖诱导的心肌细胞和内皮细胞功能障碍中的保护作用：一项机制综述
Diabetes Metab Syndr Obes. 2025 May 1;18:1373-1388. doi: 10.2147/DMSO.S505138. eCollection 2025.
2
Targeted HS-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia-Reperfusion Injury by Platelet Membrane.基于血小板膜具有pH敏感释放特性的靶向热休克介导气体疗法治疗心肌缺血再灌注损伤
Biomater Res. 2024 Aug 19;28:0061. doi: 10.34133/bmr.0061. eCollection 2024.
3
Role of hydrogen sulfide in health and disease.

本文引用的文献

1
Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.硫化氢、氢过硫化物及其衍生物种的氧化还原化学与化学生物学：其潜在生物活性和用途的意义
Free Radic Biol Med. 2014 Dec;77:82-94. doi: 10.1016/j.freeradbiomed.2014.09.007. Epub 2014 Sep 16.
2
Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.硫化氢（H₂S）释放剂：化学与生物学应用
Chem Commun (Camb). 2014 Oct 14;50(80):11788-805. doi: 10.1039/c4cc00968a.
3
Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease.
硫化氢在健康与疾病中的作用。
MedComm (2020). 2024 Aug 16;5(9):e661. doi: 10.1002/mco2.661. eCollection 2024 Sep.
4
Pills of Multi-Target HS Donating Molecules for Complex Diseases.用于复杂疾病的多靶点 HS 供体分子的药丸。
Int J Mol Sci. 2024 Jun 27;25(13):7014. doi: 10.3390/ijms25137014.
5
Benzylic Trifluoromethyl Accelerates 1,6-Elimination Toward Rapid Probe Activation.苄基三氟甲基加速1,6-消除反应以实现快速探针激活。
bioRxiv. 2024 May 31:2024.05.30.596105. doi: 10.1101/2024.05.30.596105.
6
Curcumin reduces myocardial ischemia-reperfusion injury, by increasing endogenous HS levels and further modulating mA.姜黄素通过增加内源性 HS 水平和进一步调节 mA 来减少心肌缺血再灌注损伤。
Mol Biol Rep. 2024 Apr 20;51(1):558. doi: 10.1007/s11033-024-09478-6.
7
Thioglucose-derived tetrasulfide, a unique polysulfide model compound.硫代葡萄糖衍生的四硫化物，一种独特的多硫化物模型化合物。
Redox Biol. 2024 Apr;70:103045. doi: 10.1016/j.redox.2024.103045. Epub 2024 Jan 17.
8
HS Donors with Cytoprotective Effects in Models of MI/R Injury and Chemotherapy-Induced Cardiotoxicity.在心肌梗死/再灌注损伤和化疗诱导的心脏毒性模型中具有细胞保护作用的造血干细胞供体。
Antioxidants (Basel). 2023 Mar 5;12(3):650. doi: 10.3390/antiox12030650.
9
Comparative Study of Different HS Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage.不同造血干细胞供体作为血管舒张剂和超氧化物诱导的内皮损伤减弱剂的比较研究
Antioxidants (Basel). 2023 Feb 1;12(2):344. doi: 10.3390/antiox12020344.
10
Research Progress of HS Donors Conjugate Drugs Based on ADTOH.基于 ADTOH 的 HS 供体偶联药物的研究进展。
Molecules. 2022 Dec 31;28(1):331. doi: 10.3390/molecules28010331.
内源性气体信号分子硫化氢在心血管疾病中的作用。
Circ Res. 2014 Feb 14;114(4):730-7. doi: 10.1161/CIRCRESAHA.114.300505.
4
Detection of protein S-sulfhydration by a tag-switch technique.通过标签切换技术检测蛋白质 S-巯基化。
Angew Chem Int Ed Engl. 2014 Jan 7;53(2):575-81. doi: 10.1002/anie.201305876. Epub 2013 Nov 29.
5
Hydrogen sulfide and translational medicine.硫化氢与转化医学。
Acta Pharmacol Sin. 2013 Oct;34(10):1284-91. doi: 10.1038/aps.2013.127.
6
Hydrogen sulphide vasodilates human pulmonary arteries: a possible role in pulmonary hypertension?硫化氢舒张人肺动脉：在肺动脉高压中可能起作用？
Microvasc Res. 2013 Nov;90:135-7. doi: 10.1016/j.mvr.2013.09.002. Epub 2013 Sep 13.
7
A tale of two gases: NO and H2S, foes or friends for life?两种气体的故事：一氧化氮和硫化氢，是生命的敌人还是朋友？
Redox Biol. 2013 May 23;1(1):313-8. doi: 10.1016/j.redox.2013.05.001.
8
Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments.基于硫化氢的治疗方法与胃肠道疾病：将生理学转化为治疗方法。
Am J Physiol Gastrointest Liver Physiol. 2013 Oct 1;305(7):G467-73. doi: 10.1152/ajpgi.00169.2013. Epub 2013 Jul 18.
9
Hydrogen sulfide chemical biology: pathophysiological roles and detection.硫化氢的化学生物学：病理生理作用与检测。
Nitric Oxide. 2013 Nov 30;35:5-20. doi: 10.1016/j.niox.2013.07.002. Epub 2013 Jul 9.
10
Hydrogen sulfide: potent regulator of vascular tone and stimulator of angiogenesis.硫化氢：血管张力的强效调节剂和血管生成的刺激剂。
Int J Biomed Sci. 2012 Jun;8(2):81-6.