Gerhart-Hines Z, Lazar M A
Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Diabetes Obes Metab. 2015 Sep;17 Suppl 1(0 1):12-6. doi: 10.1111/dom.12510.
The circadian clock orchestrates the co-ordinated rhythmicity of numerous metabolic pathways to anticipate daily and seasonal changes in energy demand. This vital physiological function is controlled by a set of individual clock components that are present in each cell of the body, and regulate each other as well as clock output genes. A key factor is the nuclear receptor, Rev-erbα, a transcriptional repressor which functions not only as a clock component but also as a modulator of metabolic programming in an array of tissues. This review explores the role of Rev-erbα in mediating this crosstalk between circadian rhythm and tissue-specific biological networks and its relevance to organismal physiology.
昼夜节律时钟协调众多代谢途径的协同节律，以预测能量需求的每日和季节性变化。这一重要的生理功能由一组存在于身体每个细胞中的个体时钟组件控制，这些组件相互调节以及调节时钟输出基因。一个关键因素是核受体Rev-erbα，它是一种转录抑制因子，不仅作为时钟组件发挥作用，还作为一系列组织中代谢编程的调节剂。本综述探讨了Rev-erbα在介导昼夜节律与组织特异性生物网络之间的这种相互作用及其与机体生理学相关性方面的作用。
