新生儿保育室中耐庆大霉素金黄色葡萄球菌菌株引起的感染
Infections due to gentamicin-resistant Staphylococcus aureus strain in a nursery for neonatal infants.
作者信息
Vogel L, Nathan C, Sweeney H M, Kabins S A, Cohen S
出版信息
Antimicrob Agents Chemother. 1978 Mar;13(3):466-72. doi: 10.1128/AAC.13.3.466.
Abstract
An apparently homogeneous strain of Staphylococcus aureus resistant to gentamicin (Gmr), kanamycin, tobramycin, and sisomicin, but susceptible to amikacin and netilmicin, caused multiple infections in neonatal infants in a special care nursery. Nasal cultures revealed a high rate of carriage of the Gmr staphylococcus in infants without clinical infection. Segregating patients according to a modified cohort system and use of careful aseptic techniques led to apparent elimination of the Gmr strain. The resistance to aminoglycosides in this strain was mediated by an aminoglycoside 6'-N-acetyltransferase and a gentamicin phosphotransferase. Genetic determinants for these enzymes were borne on a circular covalently closed plasmid of approximately 11 megadaltons. These resistance determinants closely resemble those found in isolates of S. aureus that have caused nosocomial infections in patients in Europe.
摘要
一株对庆大霉素（Gmr）、卡那霉素、妥布霉素和西索米星耐药，但对阿米卡星和奈替米星敏感的金黄色葡萄球菌，在一个特殊护理新生儿病房导致新生儿发生了多次感染。鼻腔培养显示，在无临床感染的婴儿中，Gmr葡萄球菌的携带率很高。根据改良队列系统对患者进行隔离，并采用严格的无菌技术，使Gmr菌株明显消失。该菌株对氨基糖苷类抗生素的耐药性由一种氨基糖苷6'-N-乙酰转移酶和一种庆大霉素磷酸转移酶介导。这些酶的遗传决定因子存在于一个约11兆道尔顿的共价闭合环状质粒上。这些耐药决定因子与在欧洲医院感染患者中分离出的金黄色葡萄球菌菌株中发现的耐药决定因子非常相似。
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