可使阿米卡星磷酸化的具有广泛底物范围的质粒介导的氨基糖苷磷酸转移酶。
Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin.
作者信息
Courvalin P, Davies J
出版信息
Antimicrob Agents Chemother. 1977 Apr;11(4):619-24. doi: 10.1128/AAC.11.4.619.
Abstract
A plasmid-mediated aminoglycoside phosphotransferase that phosphorylates amikacin has been detected in clinical isolates of Staphylococcus aureus. This enzyme does not confer detectable amikacin resistance to the strains.
摘要
在金黄色葡萄球菌的临床分离株中检测到一种可使阿米卡星磷酸化的质粒介导的氨基糖苷磷酸转移酶。该酶并未使这些菌株产生可检测到的对阿米卡星的耐药性。
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本文引用的文献
1
Antibiotic susceptibility testing by a standardized single disk method.采用标准化单纸片法进行抗生素敏感性试验。
Am J Clin Pathol. 1966 Apr;45(4):493-6.
2
Mechanisms of antibiotic resistance in bacteria.细菌中的抗生素耐药机制。
Annu Rev Biochem. 1973;42:471-506. doi: 10.1146/annurev.bi.42.070173.002351.
3
Enzymes that inactivate antibiotics in transit to their targets.在抗生素到达其靶点的过程中使其失活的酶。
Ann N Y Acad Sci. 1974 May 10;235(0):130-6. doi: 10.1111/j.1749-6632.1974.tb43262.x.
4
Evolution of plasmids in vivo in a strain of Staphylococcus aureus.
J Med Microbiol. 1974 Feb;7(1):117-25. doi: 10.1099/00222615-7-1-117.
5
Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus.金黄色葡萄球菌中一种隐蔽性高频转导噬菌体的特性
Virology. 1967 Sep;33(1):155-66. doi: 10.1016/0042-6822(67)90105-5.
6
Isolation and characterization of a kanamycin resistance plasmid from Staphylococcus aureus.从金黄色葡萄球菌中分离并鉴定一种卡那霉素抗性质粒。
Antimicrob Agents Chemother. 1974 Oct;6(4):516-20. doi: 10.1128/AAC.6.4.516.
7
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8
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.氨基糖苷类抗生素的酶促修饰：一株铜绿假单胞菌分离株中的一种新型3-N-乙酰化酶
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9
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