Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana 143, Korle-Bu, Accra, Ghana.
College of Agriculture and Natural Sciences, School of Biological Sciences, Department of Molecular Biology and Biotechnology, University of Cape Coast Cape Coast, Ghana.
Immun Inflamm Dis. 2015 Sep;3(3):133-40. doi: 10.1002/iid3.66. Epub 2015 Jun 16.
Platelet-derived extracellular vesicles (PEVs) are described as sub-cellular vesicles released into circulation upon platelets shear stress, activation, injury, or apoptosis. They are considered as universal biomarkers in a wide range of physiological and pathological processes. They are of tremendous significance for the prediction, diagnosis, and observation of the therapeutic success of many diseases. Understanding their biosynthesis and therefore functional properties would contribute to a better understanding of the pathological mechanisms leading to various diseases in which their levels are raised and they are implicated. The review takes a critical look at the historical background of PEVs, their structural components, the mechanism of their formation, physiological, and exogenous stimuli inducing their release and their detection. It concludes by highlighting on the importance of undertaking in-depth studies into PEVs biosynthesis and subsequently gaining a better understanding of their biological role in general.
血小板衍生的细胞外囊泡 (PEVs) 是指在血小板剪切应力、激活、损伤或凋亡时释放到循环中的亚细胞囊泡。它们被认为是广泛的生理和病理过程中的通用生物标志物。它们对于许多疾病的预测、诊断和治疗效果观察具有重要意义。了解它们的生物合成及其功能特性将有助于更好地理解导致其水平升高并与之相关的各种疾病的病理机制。本综述批判性地回顾了 PEVs 的历史背景、其结构成分、形成机制、生理和外源刺激诱导其释放及其检测。最后强调了深入研究 PEVs 生物合成的重要性，并随后更好地理解其在一般生物学中的作用。
