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本文引用的文献

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Head-to-Head Comparison of the RNA-Based Aptima Human Papillomavirus (HPV) Assay and the DNA-Based Hybrid Capture 2 HPV Test in a Routine Screening Population of Women Aged 30 to 60 Years in Germany.德国30至60岁女性常规筛查人群中基于RNA的Aptima人乳头瘤病毒(HPV)检测与基于DNA的杂交捕获2 HPV检测的直接比较
J Clin Microbiol. 2015 Aug;53(8):2509-16. doi: 10.1128/JCM.01013-15. Epub 2015 May 27.
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Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status.HPV-mRNA在pN0状态宫颈癌患者前哨淋巴结中的预后价值。
Oncotarget. 2015 Sep 8;6(26):23015-25. doi: 10.18632/oncotarget.4132.
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Autoantibody Signatures Combined with Epstein-Barr Virus Capsid Antigen-IgA as a Biomarker Panel for the Detection of Nasopharyngeal Carcinoma.自身抗体特征联合爱泼斯坦-巴尔病毒衣壳抗原-IgA作为检测鼻咽癌的生物标志物组合
Cancer Prev Res (Phila). 2015 Aug;8(8):729-36. doi: 10.1158/1940-6207.CAPR-14-0397. Epub 2015 May 19.
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Screening of cervical cancer in Catalonia 2006-2012.2006 - 2012年加泰罗尼亚地区宫颈癌筛查情况
Ecancermedicalscience. 2015 Apr 29;9:532. doi: 10.3332/ecancer.2015.532. eCollection 2015.
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Performance of HPV DNA testing in the follow-up after treatment of high-grade cervical lesions, adenocarcinoma in situ (AIS) and microinvasive carcinoma.人乳头瘤病毒(HPV)DNA检测在高级别宫颈病变、原位腺癌(AIS)及微浸润癌治疗后随访中的应用
Ecancermedicalscience. 2015 Apr 29;9:528. doi: 10.3332/ecancer.2015.528. eCollection 2015.
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肿瘤标志物的转化研究进展。

Translational progress on tumor biomarkers.

机构信息

Key Laboratory of Longevity and Aging-Related Diseases, Ministry of Education Nanning, China ; Center for Translational Medicine, Guangxi Medical University Nanning, China.

Department of Urology and Pathology, School of Medicine, University of Michigan Ann Arbor, Michigan, USA.

出版信息

Thorac Cancer. 2015 Nov;6(6):665-71. doi: 10.1111/1759-7714.12294. Epub 2015 Jul 27.

DOI:10.1111/1759-7714.12294
PMID:26557902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4632916/
Abstract

There is an urgent need to apply basic research achievements to the clinic. In particular, mechanistic studies should be developed by bench researchers, depending upon clinical demands, in order to improve the survival and quality of life of cancer patients. To date, translational medicine has been addressed in cancer biology, particularly in the identification and characterization of novel tumor biomarkers. This review focuses on the recent achievements and clinical application prospects in tumor biomarkers based on translational medicine.

摘要

迫切需要将基础研究成果应用于临床。具体而言,应当根据临床需求由 bench 研究人员开展机制研究,以提高癌症患者的生存率和生活质量。迄今为止,转化医学已在癌症生物学中得到了研究,特别是在新型肿瘤标志物的鉴定和特征描述方面。本文重点介绍了基于转化医学的肿瘤标志物的最新研究进展和临床应用前景。