Nankivil Derek, Waterman Gar, LaRocca Francesco, Keller Brenton, Kuo Anthony N, Izatt Joseph A
Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Department of Ophthalmology, Duke University Medical Center, Durham, NC, 27710, USA.
Biomed Opt Express. 2015 Oct 21;6(11):4516-28. doi: 10.1364/BOE.6.004516. eCollection 2015 Nov 1.
We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for both imaging modes, and the optical paths for each imaging mode were optimized for their respective application using a combination of commercial and custom optics. The system has a working distance of 26.1 mm and a measured axial resolution of 8 μm (in air). In posterior segment mode, the design has a lateral resolution of 9 μm, 7.4 mm imaging depth range (in air), 4.9 mm 6dB fall-off range (in air), and peak sensitivity of 103 dB over a 22° field of view (FOV). In anterior segment mode, the design has a lateral resolution of 24 μm, imaging depth range of 7.4 mm (in air), 6dB fall-off range of 4.5 mm (in air), depth-of-focus of 3.6 mm, and a peak sensitivity of 99 dB over a 17.5 mm FOV. In addition, the probe includes a wide-field iris imaging system to simplify alignment. A fold mirror assembly actuated by a bi-stable rotary solenoid was used to switch between anterior and posterior segment imaging modes, and a miniature motorized translation stage was used to adjust the objective lens position to correct for patient refraction between -12.6 and + 9.9 D. The entire probe weighs less than 630 g with a form factor of 20.3 x 9.5 x 8.8 cm. Healthy volunteers were imaged to illustrate imaging performance.
我们描述了首个能够快速连续成像眼睛前段和后段的手持式扫频光学相干断层扫描（SSOCT）系统。两种成像模式均采用单个二维微机电系统（MEMS）扫描仪，并且使用商用和定制光学元件的组合，针对各自的应用优化了每种成像模式的光路。该系统的工作距离为26.1毫米，测量的轴向分辨率为8微米（在空气中）。在后段模式下，该设计的横向分辨率为9微米，成像深度范围为7.4毫米（在空气中），6分贝衰减范围为4.9毫米（在空气中），在22°视场（FOV）内的峰值灵敏度为103分贝。在前段模式下，该设计的横向分辨率为24微米，成像深度范围为7.4毫米（在空气中），6分贝衰减范围为4.5毫米（在空气中），焦深为3.6毫米，在17.5毫米视场内的峰值灵敏度为99分贝。此外，探头包括一个宽视野虹膜成像系统以简化对准。由双稳态旋转螺线管驱动的折叠镜组件用于在前段和后段成像模式之间切换，并且使用微型电动平移台来调整物镜位置，以校正-12.6至+9.9屈光度之间的患者屈光不正。整个探头重量小于630克，外形尺寸为20.3×9.5×8.8厘米。对健康志愿者进行了成像以说明成像性能。
