Tam Charmaine S, Rigas Georgia, Heilbronn Leonie K, Matisan Tania, Probst Yasmine, Talbot Michael
The Charles Perkins Centre and School of Biological Sciences, University of Sydney, Sydney, Australia.
Upper Gastrointestinal Unit, Department of Surgery, St George Private Hospital, Suite 3, Level 5, 1 South St, Kogarah, Australia.
Obes Surg. 2016 Feb;26(2):459-63. doi: 10.1007/s11695-015-1972-4.
Non-surgical weight loss induces a greater than expected decrease in energy expenditure, a phenomenon known as 'metabolic adaptation'. The effects of different bariatric surgery procedures on metabolic adaptation are not yet known and may partially contribute to weight loss success. We compared resting energy expenditure (REE) in 35 subjects (nine males; age = 46 ± 11 years; BMI = 42.1 ± 6.5 kg/m(2)) undergoing gastric band, sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) up to 2 years after surgery. We found a greater than expected reduction of 130-300 kcal/day at 6 weeks after sleeve and bypass surgery which was not explained by changes in body composition; this change was not seen in the band group. The suppression in REE after sleeve and RYGB remained up to 2 years, even after weight loss had plateaued. Our findings suggest that energy adaptation is not a contributing mechanism to medium-term weight maintenance after sleeve and RYGB bariatric surgeries.
非手术减肥导致能量消耗的下降幅度大于预期，这一现象被称为“代谢适应”。不同的减肥手术程序对代谢适应的影响尚不清楚，可能部分促成了减肥的成功。我们比较了35名接受胃束带术、袖状胃切除术或Roux-en-Y胃旁路术（RYGB）的受试者（9名男性；年龄=46±11岁；BMI=42.1±6.5kg/m²）术后长达2年的静息能量消耗（REE）。我们发现，袖状胃切除术和胃旁路术后6周时，能量消耗比预期减少了130 - 300千卡/天，且这一减少无法用身体成分的变化来解释；胃束带术组未出现这种变化。袖状胃切除术和RYGB术后，即使体重减轻已趋于平稳，REE的抑制仍持续长达2年。我们的研究结果表明，能量适应并非袖状胃切除术和RYGB减肥手术后中期体重维持的促成机制。
