Meade H M, Signer E R
Proc Natl Acad Sci U S A. 1977 May;74(5):2076-8. doi: 10.1073/pnas.74.5.2076.
The drug resistance factor RP4, originally isolated in Pseudomonas, was transferred to Rhizobium meliloti. In that strain, RP4 promotes conjugational transfer of chromosomal markers to form haploid recombinants. This mating system has been used to construct a linkage map of R. meliloti.
最初在假单胞菌中分离得到的抗药因子RP4被转移到了苜蓿根瘤菌中。在该菌株中,RP4促进染色体标记的接合转移以形成单倍体重组体。这种交配系统已被用于构建苜蓿根瘤菌的连锁图谱。