Um Eun Hae, Hwang Shin, Song Gi-Won, Jung Dong-Hwan, Ahn Chul-Soo, Kim Ki-Hun, Moon Deok-Bog, Park Gil-Chun, Lee Sung-Gyu
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Korean J Hepatobiliary Pancreat Surg. 2015 Nov;19(4):133-8. doi: 10.14701/kjhbps.2015.19.4.133. Epub 2015 Nov 30.
BACKGROUNDS/AIMS: Standard liver volume (SLV) is an important parameter that has been used as a reference value to estimate the graft matching in living donor liver transplantation (LDLT). This study aimed to determine a reliable SLV formula for Korean adult patients as compared with the 15 SLV formulae from other studies and further estimate SLV formula by gender and body mass index (BMI).
Computed tomography liver volumetry was performed in 1,000 living donors for LDLT and regression formulae for SLV was calculated. Individual donor data were applied to the 15 previously published SLV formulae, as compared with the SLV formula derived in this study. Analysis for confounding variables of BMI and gender was also performed.
Two formulae, "SLV (ml)=908.204×BSA-464.728" with DuBois body surface area (BSA) formula and "SLV (ml)=893.485×BSA-439.169" with Monsteller BSA formula, were derived by using the profiles of the 1,000 living donors included in the study. Comparison with other 15 other formulae, all except for Chouker formula showed the mean volume percentage errors of 4.8-5.4%. The gender showed no significant effect on total liver volume (TLV), but there was a significant increase in TLV as BMI increased.
Our study suggested that most SLV formulae showed a crudely applicable range of SLV estimation for Korean adults. Considering the volume error in estimating SLV, further SLV studies with larger population from multiple centers should be performed to enhance its predictability. Our results suggested that classifying SLV formulae by BMI and gender is unnecessary.
背景/目的：标准肝体积（SLV）是一个重要参数，已被用作活体肝移植（LDLT）中评估供肝匹配的参考值。本研究旨在确定一个适用于韩国成年患者的可靠SLV公式，并与其他研究中的15个SLV公式进行比较，进一步按性别和体重指数（BMI）估算SLV公式。
对1000例LDLT活体供者进行肝脏CT容积测量，并计算SLV的回归公式。将个体供者数据应用于先前发表的15个SLV公式，并与本研究得出的SLV公式进行比较。还对BMI和性别的混杂变量进行了分析。
利用本研究纳入的1000例活体供者的资料，得出了两个公式，即采用杜波依斯体表面积（BSA）公式的“SLV（ml）=908.204×BSA - 464.728”和采用蒙斯特勒BSA公式的“SLV（ml）=893.485×BSA - 439.169”。与其他15个公式比较，除乔克公式外，所有公式的平均体积百分比误差为4.8 - 5.4%。性别对全肝体积（TLV）无显著影响，但随着BMI增加，TLV显著增加。
我们的研究表明，大多数SLV公式对韩国成年人的SLV估算显示出大致适用范围。考虑到SLV估算中的体积误差，应进行来自多个中心的更大样本量的进一步SLV研究，以提高其预测性。我们的结果表明，按BMI和性别对SLV公式进行分类是不必要的。
