酒精与艾滋病毒对免疫系统的影响
Alcohol and HIV Effects on the Immune System.
作者信息
Bagby Gregory J, Amedee Angela M, Siggins Robert W, Molina Patricia E, Nelson Steve, Veazey Ronald S
机构信息
Tulane National Primate Research Center, Covington, Louisiana.
出版信息
Alcohol Res. 2015;37(2):287-97.
Abstract
HIV disease and alcohol independently influence the human immune system, so it stands to reason that, together, their influence may be additive. Here, we review the evidence that alcohol can exacerbate HIV's influence on the immune system, thereby affecting disease progression and transmission. We focus particularly on alcohol's effect on the mucosal immune system in the tissues of the gastrointestinal tract, the genital tract and the lungs, all of which play a role in transmission and progression of HIV disease.
摘要
艾滋病毒感染与酒精独立地影响人体免疫系统，因此可以合理推断，二者共同作用时，其影响可能具有叠加性。在此，我们综述相关证据，即酒精会加剧艾滋病毒对免疫系统的影响，进而影响疾病进展与传播。我们特别关注酒精对胃肠道、生殖道及肺部组织黏膜免疫系统的影响，所有这些组织在艾滋病毒感染疾病的传播与进展中均发挥作用。
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